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Mild TBI Assessment & Rehabilitation Study

This study is looking at ways to help Veterans who have experienced a mild traumatic brain injury (TBI) and are dealing with lasting cognitive (thinking) and emotional challenges. Researchers are testing two approaches: Goal-Oriented Attentional Self-Regulation (GOALS), which is a cognitive training program, and Brain Health Education (BHE), which provides information about brain function. The goal is to see if GOALS can improve daily life for Veterans with mild TBI by helping them with attention and goal management. To join, you need to be a Veteran aged 18 or older with a history of mild TBI (more than 6 months ago) and report ongoing cognitive difficulties. Success will be measured by improvements in executive function (thinking skills) using a specific task called the Delis-Kaplan Executive Function System (D-KEFS) Stroop Inhibition-Switching Task, measured 6 months after you join. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 65 participants. Participants will be assigned to either the GOALS program or the Brain Health Education group.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be assessed 6 months after you enroll in the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT02920788

Mild TBI Assessment & Rehabilitation

Recruiting
NAAges 18+InterventionalTreatment
VA Office of Research and Development
~65 participants
Updated 2026-05-06 on ClinicalTrials.gov
What's tested:Goal-Oriented Attentional Self-Regulation (GOALS)Brain Health Education (BHE)fMRI

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Delis-Kaplan Executive Function System (D-KEFS) Stroop Inhibition-Switching Task
Measured over 6 months after enrollment

Conditions

Brain Injuries, Traumatic

Explore related trials

Traumatic Encephalopathy

Where it's being run

2 sites across 1 states
California2

Study leadership

  • Pratik Mukherjee, MD PhD · PRINCIPAL_INVESTIGATOR · San Francisco VA Medical Center, San Francisco, CA

Who to contact

Pratik Mukherjee, MD PhD
[email protected]
(415) 353-9364
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ages 18+
A history of mild TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument)
Chronic, stable phase of recovery (\>6 months from last post-concussive event)
Report of residual cognitive difficulties (1 moderate or severe cognitive symptom(s) on the Neurobehavioral Symptom Inventory (NSI)) that interfere(s) with daily function
Able and willing to commit to participate in training and assessments
If on psychoactive medications, must be stable on medications (\> 30 days)
Ages 18+
No history of any (mild to severe) TBI (as defined by DOD / VA; confirmed by medical records and in person Ohio State University TBI Instrument)
Able and willing to commit to participate in assessments
If on psychoactive medications, must be stable on medications (\> 30 days)

Exclusion

A history of moderate or severe TBI
Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g., contraindications to MRI)
Ongoing illicit drug or alcohol abuse (AUDIT\>8)
Psychosis
Severe depression, anxiety or PTSD that precludes participation in research activities
Poor English comprehension
Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD
There will be no restriction in regard to gender, race and socioeconomic status
A history of any mild, moderate, or severe TBI
Unstable medical, neurologic, or psychiatric condition, including severe cognitive dysfunction, or other reasons for being unable or unwilling to participate in study procedures (e.g. contraindications to MRI)
Ongoing illicit drug or alcohol abuse (AUDIT\>8)
Psychosis
Severe depression, anxiety or PTSD that precludes participation in research activities
Poor English comprehension
Eligible participants may have other co-morbid stable neuropsychiatric disorders, including depression and PTSD.
There will be no restriction in regard to gender, race and socioeconomic status

What this trial measures

  • Delis-Kaplan Executive Function System (D-KEFS) Stroop Inhibition-Switching Task6 months after enrollment

    Single Test for Attention, Executive Function and Mental Flexibility