Vascular Function in Health and Disease Study

This study is looking at how blood vessels work in people with certain health conditions like Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Artery Hypertension, Heart Failure, and Hypertension, as well as in healthy individuals. Researchers are testing several interventions including exercise tests, and drugs like BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid, L-Ascorbate, BQ-123, Fexofenadine, Ranitidine, Angiotensin-II, and Valsartan. The goal is to see how these interventions change blood flow in your limbs. You might be able to join if you are a healthy young adult (18-30), a healthy older adult (65+), or a patient undergoing routine coronary angiography. The study is currently unclear on its recruitment status and plans to enroll 420 participants.

Study design: This is an interventional study with a planned enrollment of 420 participants. It is not specified if it is randomized or blinded.
What's involved: You would undergo various exercise tests, have catheters placed in your femoral artery and vein, and have measurements of blood pressure, heart rate, and blood flow taken. You would also participate in flow-mediated vasodilation tests and exercise bouts.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoint, change in limb blood flow, is measured at baseline and 1 hour after intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

: Vascular Function in Health and Disease

Recruiting

PHASE1Ages 18+InterventionalBasic science

Russell Richardson

~420 participants

Updated 2025-09-26 on ClinicalTrials.gov

What's tested:Maximum Exercise TestsBH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-AscorbateBQ-123Fexofenadine, RanitidineAngiotensin-II, ValsartanAcetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Change in Limb Blood Flow

Measured over Baseline and 1 hour

Conditions

Chronic Obstructive Pulmonary Disease

Pulmonary Artery Hypertension

Heart Failure

Hypertension

NCT02966665

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

George E Wahlen VA Medical Center
Salt Lake City, Utahstudy coordinator listed
Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

Russell Richardson, Ph.D. · PRINCIPAL_INVESTIGATOR · George E Wahlen VA Medical Center

Who to contact

Maydeen Ogara

[email protected]

801-584-2522

Email the study team

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Eligibility criteria

Inclusion

Healthy Young Volunteers: 18-30 years of age with no diseases or conditions that would affect their participation in the study

Healthy Older Controls: volunteers 65 years of age or older with no diseases or conditions that would affect their participation in the study

Coronary Angiography subjects: patients undergoing routine coronary angiography

Chronic Obstructive Pulmonary Disease subjects: patients diagnosed with mild to moderate COPD

Pulmonary Arterial Hypertension subjects: patients with idiopathic or heritable Group 1 pulmonary arterial hypertension

Heart Failure subjects: patients with Class I, II or III New York Heart Association symptoms of Heart Failure

Hypertension subjects: patients diagnosed with chronic high blood pressure

Exclusion

Severe COPD (use of supplemental oxygen, or have a one-second forced expiratory volume of less than 30% predicted)

History of myocardial infarction

History of percutaneous coronary revascularization

History of coronary artery bypass grafting

Unstable angina pectoris

History of variant angina

Ejection fraction \< 50%

Significant renal disease (Glomerular Filtration Rate \< 50 mL/min/1.73m2)

Subjects whose medical care or safety may be at risk from undergoing a Magnetic Resonance Imaging examination (e.g. pacemaker, metal implants, certain types of heart valves)

Subject is pregnant

Subject has physical ailments (other than COPD, PAH, HF, or hypertension) that would prevent them from study participation in the judgment of the investigator

What this trial measures

Change in Limb Blood FlowBaseline and 1 hour
Change in local limb blood flow as measured by ultrasound Doppler in units of milliliters per minute (mL/min) from baseline to up to 1 hour following study interventions

Trialytics