VCRC Tissue Repository for Vasculitis Research

This study, called the VCRC Tissue Repository, is collecting existing tissue samples from people who are already part of other Vasculitis Clinical Research Consortium (VCRC) studies. The goal is to identify genes that might increase the risk of developing vasculitis, a group of diseases that cause inflammation of blood vessels. Researchers will analyze these tissue samples, along with your health information from other VCRC studies, to better understand conditions like Aortitis, Cutaneous Vasculitis, Eosinophilic Granulomatosis With Polyangiitis, Giant Cell Arteritis, and Granulomatosis With Polyangiitis (Wegener's). This research aims to help scientists find new ways to diagnose and treat these diseases. This study is currently unclear on its recruitment status.

Study design
This is an observational study, meaning researchers will collect and analyze existing information without giving new treatments. It plans to include up to 1000 participants.
What's involved
You would not have any extra visits or procedures for this study. Researchers will request your permission to use tissue samples (like from a kidney, lung, or skin biopsy) that were already collected as part of your routine medical care.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of identifying genes that increase vasculitis risk will be measured at 1 year.

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NCT02967068

VCRC Tissue Repository

Recruiting
Not specifiedAll AgesObservational
University of Pennsylvania
~1,000 participants
Updated 2026-01-22 on ClinicalTrials.gov

At a glance

Recruiting sites
3 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identify genes that increase the risk of developing vasculitis
Measured over 1 year
Aortitis
Cutaneous Vasculitis
Eosinophilic Granulomatosis With Polyangiitis
Giant Cell Arteritis
Granulomatosis With Polyangiitis (Wegener's)
Henoch-Schonlein Purpura
IgA Vasculitis
Microscopic Polyangiitis
Polyarteritis Nodosa
Takayasu Arteritis
Churg-Strauss Syndrome
8 sites across 5 states
Massachusetts2
Pennsylvania2
Ontario2
Ohio1
Utah1
  • Peter A Merkel, MD, MPH · STUDY_CHAIR · University of Pennsylvania

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).

Exclusion

Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
Unwilling to allow the use of their tissue for research.
  • Identify genes that increase the risk of developing vasculitis1 year

    Evaluating of clinical data and linked biopsy specimens to identify genes that increase the risk of developing vasculitis.