Diffusion MRI in Heart Failure Study

This study is investigating how changes in the heart's structure contribute to heart failure. Researchers are using Diffusion Tensor MRI (DTI), which measures water movement in the heart to understand muscle fiber orientation, and Gadolinium DOTA Meglumine, a contrast agent, to get detailed images. They hope to understand how heart failure develops and progresses. You might be able to join if you are a healthy adult, or if you've recently had a heart attack (myocardial infarction) and are stable, or if you've experienced heart failure in the last year and have left ventricular hypertrophy (thickening of the heart's main pumping chamber). The main goal is to measure the heart's muscle fiber angle after 12 months. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 160 participants. It involves using specific imaging techniques to understand heart structure.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 12 months, suggesting participants will be followed for at least that long.

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NCT02973633

Diffusion MRI in Heart Failure

Recruiting
EARLY_PHASE1Ages 18–85InterventionalDiagnostic
Massachusetts General Hospital
~160 participants
Updated 2025-12-24 on ClinicalTrials.gov
What's tested:Diffusion Tensor MRI (DTI)Gadolinium DOTA Meglumine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Myofiber Helix Angle
Measured over 12 months
Heart Failure
Myocardial Infarction
Left Ventricular Hypertrophy
1 sites across 1 states
Massachusetts1
  • David E. Sosnovik, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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Eligibility criteria

Inclusion

Healthy adults with no history of hypertension, diabetes or heart disease
Patients with ST Elevation MI within last 6-10 weeks who are angina free, and have been seen by a cardiologist since discharge
Patients with episode of heart failure within last 12 months and left ventricular hypertrophy, documented by echocardiogram or MRI.
  • Myofiber Helix Angle12 months

    The investigators aim to determine how the myofibers in the heart change their orientation in heart disease by measuring their helix angle.