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LD Lync Study: Understanding Lipodystrophy Syndromes

This study, called the LD Lync Study, is an observational study looking at lipodystrophy syndromes, which are rare conditions where your body loses fat tissue. This can lead to health problems like diabetes, high cholesterol, and liver issues. Researchers want to understand more about how often diabetes occurs in people with lipodystrophy over four years. You might be able to join if you have a clinical diagnosis of genetic or acquired lipodystrophy, supported by genetic test results or other medical information. This study is not testing a new medicine, but rather observing the natural course of the condition to learn more about it. The study aims to enroll 500 participants.

Study design
This is an observational study, meaning researchers will be watching and collecting information without giving any specific treatments. It aims to include 500 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to measure the prevalence of diabetes mellitus at 4 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03087253

The LD Lync Study - Natural History Study of Lipodystrophy Syndromes

Recruiting
Not specifiedAll AgesObservational
University of Michigan
~500 participants
Updated 2026-03-19 on ClinicalTrials.gov

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Prevalence of diabetes mellitus
Measured over 4 years

Conditions

Lipodystrophy (Genetic or Acquired, Non HIV)

Explore related trials

Lipodystrophy

Where it's being run

4 sites across 4 states
Maryland1
Michigan1
Ceará1
Turkey (Türkiye)1

Study leadership

  • Elif A Oral, MD · PRINCIPAL_INVESTIGATOR · Professor of Medicine

Who to contact

Adam Neidert, M.S.
[email protected]
734-615-0539
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Clinical diagnosis of genetic or acquired lipodystrophy Supportive data: 1) Presence of biallelic known disease-causing variants in the genes for autosomal recessive lipodystrophy syndromes; 2) Presence of a known (or de novo loss of function) disease-causing variant in the genes for autosomal dominant lipodystrophy syndromes; or 3) Clinical supportive data based on morphological criteria together with metabolic abnormalities.

Exclusion

HIV-infected patients with lipodystrophy
Drug-induced lipodystrophy

What this trial measures

  • Prevalence of diabetes mellitus4 years

    Number of subjects with diabetes mellitus or who develop diabetes mellitus