HYDRA Treatment for Laryngeal Cancer

This study is testing a radiation treatment called Stereotactic Hypofractionated Radioablation (HYDRA) for people with laryngeal cancer (cancer of the voice box). The main goal is to find the highest dose of HYDRA radiation that can be given safely. Researchers will also study how safe this treatment is. You might be able to join if you are over 18, have squamous cell carcinoma of the larynx, and meet other health criteria. The study is currently unclear on its recruitment status and aims to enroll 11 participants.

Study design
This study is an interventional trial with an unclear phase, planning to enroll 11 participants. Participants will be assigned to increasing doses of HYDRA radiation in groups until the highest tolerable dose is found.
What's involved
You would receive HYDRA radiation over about two weeks, for a total of up to 5 times. You will also complete quality of life and symptom questionnaires at several points over at least 6 months.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for at least 6 months after your last dose of HYDRA, with follow-up visits every 3 months for the first 2 years, and then every 6 months after that.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03114462

Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer

Recruiting
PHASE1Ages 18+InterventionalTreatment
M.D. Anderson Cancer Center
~11 participants
Updated 2026-04-15 on ClinicalTrials.gov
What's tested:Stereotactic Hypofractionated RadioablationQuestionnaires

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximum Tolerated Dose (MTD) of Stereotactic Hypofractionated RadioAblative (HYDRA) Treatment
Measured over 180 days
Malignant Neoplasms of Respiratory and Intrathoracic Organs
Squamous Cell Carcinoma of the Larynx

NCT03114462

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • MD Anderson Cancer Center

    Houston, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Jack Phan, MD, PHD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

Opens a ready-to-send draft in your own email app — review before sending.

  • Maximum Tolerated Dose (MTD) of Stereotactic Hypofractionated RadioAblative (HYDRA) Treatment180 days

    Toxicity graded using the NCI Common Toxicity Criteria for Adverse Events (CTCAE) v. 4.0.