Allogeneic Hematopoietic Cell Transplantation for Multiple Myeloma in Medicare Beneficiaries

This observational study is looking at how well allogeneic hematopoietic stem cell transplants (alloHCT) work for people with multiple myeloma, a type of blood cancer. AlloHCT is the only treatment that might cure multiple myeloma, but it can have serious side effects. Researchers will compare the outcomes of people who receive an alloHCT with those who receive an autologous HCT (autoHCT), which uses your own stem cells. To join, you must be a Medicare beneficiary with Stage II or III multiple myeloma or primary plasma cell leukemia, and be eligible for an alloHCT at a US transplant center. The main goal is to see how many people are still alive five years after their transplant.

Study design
This is an observational study that aims to enroll 544 participants. It compares outcomes for those receiving allogeneic HCT with a matched group receiving autologous HCT.
What's involved
You would need to agree to submit comprehensive clinical data about your health before and after the transplant.
Compensation
Not stated in the trial record.
Follow-up
The study will track participants' survival for five years after their transplant.

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NCT03127761

Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries With Multiple Myeloma

Recruiting
Not specifiedAll AgesObservational
Center for International Blood and Marrow Transplant Research
~544 participants
Updated 2023-08-30 on ClinicalTrials.gov
What's tested:Allogeneic Hematopoietic Stem Cell Transplant

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Compare five-year survival
Measured over 5 years post transplant
Multiple Myeloma
1 sites across 1 states
Minnesota1
  • Anita D'Souza, MD, MS · STUDY_CHAIR · CIBMTR, Medical College of Wisconsin
  • Parameswaran Hari, MD, MS · STUDY_CHAIR · CIBMTR, Medical College of Wisconsin

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Eligibility criteria

Inclusion

Medicare beneficiary
Stage II or III multiple myeloma and/or primary plasma cell leukemia
Eligible to receive an allogeneic HCT from any suitable allogeneic donor (as determined by the transplant center) including umbilical cord blood
Will receive allogeneic HCT at a US transplant center
Agree to submit comprehensive clinical data on their pre- and post-transplant clinical status and outcomes to the CIBMTR
  • Compare five-year survival5 years post transplant

    Compare five-year overall survival between the alloHCT cohort and an age and disease risk matched cohort of autoHCT patients