Early Rheumatoid Arthritis Lung Disease Study

This study is looking at lung disease in people who have recently been diagnosed with rheumatoid arthritis (RA). Researchers want to understand how common lung problems are in early RA and what they look like. They will use lung scans (High Resolution Computed Tomography Chest Scan), breathing tests, questionnaires, and blood tests to gather this information. The study also aims to find new markers in the blood, like anti-malondialdehyde-acetaldehyde (MAA) antibodies, that might predict who will develop lung disease. You may be able to join if you are 19-90 years old and have been diagnosed with RA within the past two years. The study status is currently unclear.

Study design
This is an observational study, meaning researchers will gather information without giving any specific treatments. It plans to include 125 participants.
What's involved
You would undergo a High Resolution Computed Tomography (CT) Chest Scan at your first visit, along with pulmonary function tests, questionnaires, and serum (blood) studies. The duration of participation is not specified.
Compensation
Not stated in the trial record.
Follow-up
Your High Resolution Computed Tomography Chest Scan results will be measured at Baseline (Visit 1 only). The record mentions a goal to follow newly diagnosed RA patients long-term through electronic medical record surveys and biobank samples, but specific follow-up duration for participants is not detailed.

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NCT03192267

Early Rheumatoid Arthritis Lung Disease Study

Recruiting
Not specifiedAges 19–90Observational
University of Nebraska
~125 participants
Updated 2026-07-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
High Resolution Computed Tomography Chest Scan Results
Measured over Baseline (Visit 1 only)
Rheumatoid Arthritis
1 sites across 1 states
Nebraska1
  • Tina D Mahajan, MD · STUDY_CHAIR · University of Nebraska
  • Bryant R England, MD · PRINCIPAL_INVESTIGATOR · University of Nebraska

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Eligibility criteria

Inclusion

19-90 years of age
Able to give informed consent
Diagnosis of RA by a Rheumatologist using 2010 American College of Rheumatology (ACR) criteria within the past 2 years

Exclusion

Inflammatory arthritis that does not meet 2010 American College of Rheumatology (ACR) criteria for rheumatoid arthritis (RA)
Pregnant
  • High Resolution Computed Tomography Chest Scan ResultsBaseline (Visit 1 only)

    A high resolution computed tomography (CT) chest scan will be done at visit 1 to evaluate the presence of lung disease.