Observational Study of Liver Transplant Biopsies
This study, called INTERLIVER, is looking at liver transplant biopsies to improve how doctors diagnose problems like rejection. Researchers will use a small piece of a liver biopsy (about 5 mm) that you would already be getting for your medical care. They will use a new diagnostic system called the Molecular Microscope® Diagnostic System (MMDx) to analyze the biopsy's molecular features, along with standard biopsy results and your clinical information. The goal is to develop more accurate ways to identify T cell mediated rejection and antibody mediated rejection in liver transplants. You can join if you are 18 or older and are having a liver biopsy for clinical reasons. Pregnant women cannot participate. The study is currently unclear on its recruitment status.
- Study design
- This is an observational study planning to include 300 participants. It is not a treatment study, but rather looks at information from existing medical procedures.
- What's involved
- You would have a small piece of a liver biopsy, already scheduled for your medical care, used for gene expression study. No additional procedures are required.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary goal is to assign molecular scores within a reference set of 100 biopsies, measured at two years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation
At a glance
Conditions
Where it's being run
15 sites across 12 statesStudy leadership
- Philip F Halloran, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Alberta
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Assign molecular scores (probability) of T cell mediated rejection, antibody mediated rejection in liver transplant biopsies, in a reference set of 100 biopsiestwo years
Based on the reference set, create molecular classifier that predicts antibody mediated and T cell mediated rejection for next 200 biopsies