Observational Study of Liver Transplant Biopsies

This study, called INTERLIVER, is looking at liver transplant biopsies to improve how doctors diagnose problems like rejection. Researchers will use a small piece of a liver biopsy (about 5 mm) that you would already be getting for your medical care. They will use a new diagnostic system called the Molecular Microscope® Diagnostic System (MMDx) to analyze the biopsy's molecular features, along with standard biopsy results and your clinical information. The goal is to develop more accurate ways to identify T cell mediated rejection and antibody mediated rejection in liver transplants. You can join if you are 18 or older and are having a liver biopsy for clinical reasons. Pregnant women cannot participate. The study is currently unclear on its recruitment status.

Study design
This is an observational study planning to include 300 participants. It is not a treatment study, but rather looks at information from existing medical procedures.
What's involved
You would have a small piece of a liver biopsy, already scheduled for your medical care, used for gene expression study. No additional procedures are required.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is to assign molecular scores within a reference set of 100 biopsies, measured at two years.

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NCT03193151

Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

Recruiting
Not specifiedAges 18+Observational
University of Alberta
~300 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:liver biopsy

At a glance

Recruiting sites
1 of 15 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assign molecular scores (probability) of T cell mediated rejection, antibody mediated rejection in liver transplant biopsies, in a reference set of 100 biopsies
Measured over two years
Liver Dysfunction
15 sites across 12 states
Poland4
California1
Illinois1
Maryland1
Michigan1
Tennessee1
Texas1
Virginia1
  • Philip F Halloran, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Alberta

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

biopsy for clinical indications

Exclusion

no consent, pregnant women
  • Assign molecular scores (probability) of T cell mediated rejection, antibody mediated rejection in liver transplant biopsies, in a reference set of 100 biopsiestwo years

    Based on the reference set, create molecular classifier that predicts antibody mediated and T cell mediated rejection for next 200 biopsies