Augmenting Limb Perfusion for Peripheral Arterial Disease

This study is testing if ultrasound, combined with Definity microbubbles, can improve blood flow in the limbs of people with Peripheral Arterial Disease (PAD). PAD is a condition where narrowed arteries reduce blood flow to the limbs. Researchers have seen in previous studies that this combination can increase blood flow, and they want to find the best settings for this treatment. You may be able to join if you are 19 to 99 years old and have a confirmed diagnosis of PAD with specific symptoms (Rutherford symptom class of 4-6). The main goal is to see how much blood flow changes at 10 minutes and 60 minutes after the ultrasound treatment. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 30 participants. It is testing a specific ultrasound treatment with Definity microbubbles.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Blood flow changes will be measured at 10 minutes and 60 minutes after the ultrasound treatment.

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NCT03195556

Augmentation of Limb Perfusion With Contrast Ultrasound

Recruiting
NAAges 19–99InterventionalTreatment
Oregon Health and Science University
~30 participants
Updated 2018-08-23 on ClinicalTrials.gov
What's tested:Ultrasound

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in blood flow at 10 min
Measured over 10 min post-therapeutic ultrasound cavitation.
+1 more outcome measured
Peripheral Arterial Disease
1 sites across 1 states
Oregon1

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Eligibility criteria

Inclusion

Age ≥18 y.o.
For PAD subjects: known history of unilateral or bilateral PAD diagnosed by reduced ankle-brachial index or angiography and a Rutherford symptom class of 4-6.
  • Change in blood flow at 10 min10 min post-therapeutic ultrasound cavitation.

    Change in blood flow in calf skeletal muscle

  • Change in blood flow at 60 min60 min post-therapeutic ultrasound cavitation

    Change in blood flow in calf skeletal muscle