Observational Study on Ethanol and Muscle Autophagy in Liver Disease
This study is looking into how alcohol (ethanol) affects your muscles, specifically if it causes a process called autophagy (where cells break down and recycle their own parts). Researchers believe that alcohol changes muscle proteins, which then triggers this autophagy. They are studying people aged 18 to 65 with alcoholic liver disease, including those with fatty liver (steatosis), hepatitis, or cirrhosis. They are also including healthy control volunteers. The main goal is to see if skeletal muscle autophagy increases after 4 hours. This study is currently unclear on its recruitment status.
- Study design
- This is an observational study with a planned enrollment of 40 participants. It includes groups of patients with alcoholic liver disease and healthy controls.
- What's involved
- Participants will undergo a biopsy of the Vastus Lateralis muscle. Body composition will be measured using various methods.
- Compensation
- Not stated in the trial record.
- Follow-up
- Skeletal muscle autophagy will be measured at 4 hours after the intervention.
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Ethanol Induces Skeletal Muscle Autophagy
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Srinivasan Dasarathy, MD · PRINCIPAL_INVESTIGATOR · The Cleveland Clinic
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Skeletal Muscle Autophagy4 hours
We will measure Malonyldialdehyde Acetaldehyde protein adducts to see skeletal muscle proteolysis during a one time muscle biopsy