Oral Capecitabine and Temozolomide for Newly Diagnosed Glioblastoma

This study is looking at a new way to treat newly diagnosed glioblastoma multiforme (GBM), a type of brain tumor. It combines two chemotherapy drugs, capecitabine and temozolomide. Capecitabine is an oral chemotherapy already used for other cancers. The study wants to see if adding capecitabine to your monthly temozolomide treatment is safe and tolerable after you've completed initial radiation and temozolomide. Researchers also want to find out if this combination helps patients respond to treatment for a longer time compared to temozolomide alone, which is the current standard treatment. You may be able to join if you are 18-74 years old, have a new diagnosis of GBM, and have finished your initial chemo-radiation but haven't started monthly temozolomide yet. The study aims to measure how long patients live without their cancer growing (progression-free survival) and overall survival. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 67 participants. It is testing the combination of capecitabine and temozolomide.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will track progression-free survival at 6 months and overall survival at 4 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03213002

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM

Recruiting
PHASE1Ages 18–74InterventionalTreatment
Northwell Health
~67 participants
Updated 2026-06-01 on ClinicalTrials.gov
What's tested:CapecitabineTemozolomide

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Progression-free survival (PFS)
Measured over 6 months
+1 more outcome measured
Glioblastoma Multiforme (GBM)
Glioblastoma
Glioma of Brain
Glioblastoma, Adult
Brain Tumor
Brain Tumor, Primary
Brain Tumor Adult
Cancer
Brain Cancer
1 sites across 1 states
New York1
  • John Boockvar, MD · PRINCIPAL_INVESTIGATOR · Lenox Hill Hospital-Northwell Health

Opens a ready-to-send draft in your own email app — review before sending.

  • Progression-free survival (PFS)6 months

    PFS will be estimated by calculating the proportion of patients who are alive at 6 months from treatment commencement and are progression-free.

  • Overall Survival (OS)4 years

    OS will be calculated as the time from treatment initiation to the date of death.