Obesity, Metabolic Dysregulation, and Asthma Study
This study is looking at how obesity and metabolic syndrome (a group of conditions that increase your risk of heart disease, stroke, and type 2 diabetes) might affect the airways of people with asthma. Researchers want to understand how these conditions relate to how your body uses nitric oxide (NO) in your airways. To do this, they will collect samples from your nose and airways through a procedure called a bronchoscopy. They will then measure specific pathways related to L-arginine-NO and oxidative stress in these samples. The study is open to men and women aged 18 to 65 who have asthma, with or without obesity and metabolic syndrome. The study's status is unclear, and it plans to enroll 50 participants.
- Study design
- This is a cross-sectional pilot study comparing different groups of participants. It plans to enroll 50 participants.
- What's involved
- You would undergo a baseline evaluation, lung function testing, and a bronchoscopy with nasal epithelial brush sampling. Some participants may also have a methacholine test.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements will be taken within 6 months of sample collection.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Fernando Holguin, MD, MPH · PRINCIPAL_INVESTIGATOR · University of Colorado Denver, Anschutz Medical Campus
Who to contact
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What this trial measures
- Measurement of L-arginine-NO biosynthesis pathways in the airway epithelium in obese and non-asthmatics.Within 6 months of collection
L-arginine-NO biosynthesis pathways will be measured in the airway epithelium of mild to moderate controlled obese and non-obese asthmatics with metabolic syndrome by ELISA and western blot analysis.
- Measurement of oxidative stress in the airway epithelium in obese and non-asthmatics.Within 6 months of collection
Oxidative stress will be measured in the airway epithelium of mild to moderate controlled obese and non-obese asthmatics without metabolic syndrome by Griess Reaction and western blot analysis.