Back to search results

Comparing Single vs. Multiple Arterial Grafts in Heart Bypass Surgery

This study is comparing two types of heart bypass surgery (coronary artery bypass grafting or CABG) for people with coronary artery disease. One group will receive a single arterial graft (left internal thoracic artery) to a main heart artery, plus vein grafts for other blocked arteries. The other group will receive multiple arterial grafts, meaning at least two arteries (left internal thoracic artery and another artery like the right internal thoracic artery or radial artery) will be used for grafting. Researchers want to see if using multiple arterial grafts leads to better outcomes, like fewer deaths, strokes, heart attacks, or repeat procedures. You may be able to join if you are between 18 and 70 years old and need primary, non-emergency CABG for specific blockages. The study aims to enroll 4300 participants, but its current status is unclear.

Study design
This is a randomized study, meaning participants are randomly assigned to one of the two surgery groups. It aims to enroll at least 4,300 people across many international centers.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main outcomes will be measured more than 72 hours after surgery and/or repeat revascularization.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03217006

Randomization of Single vs Multiple Arterial Grafts

Recruiting
NAAges 18–70InterventionalTreatment
Weill Medical College of Cornell University
~4,300 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:Single arterial graftMultiple arterial grafting

At a glance

Recruiting sites
58 of 59 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Composite Outcome
Measured over > 72 hours after surgery and/or repeat revascularization

Conditions

Coronary Artery Disease
Heart Diseases

Explore related trials

Coronary Artery Disease

Where it's being run

59 sites across 22 states
Germany11
Canada9
Italy6
New York5
China5
Austria3
Portugal3
Nebraska2

Study leadership

  • Mario Gaudino, MD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University
  • Stephen Fremes, MD · PRINCIPAL_INVESTIGATOR · Sunnybrook Health Sciences Centre

Who to contact

Mario Gaudino, MD
[email protected]
212.746.1812
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Primary isolated CABG patients with disease of the left main coronary artery and/or of the left anterior descending and the circumflex coronary system with or without disease of the right coronary artery.

Exclusion

Age \> 70 years
Single graft
Emergency operation
Evolving myocardial infarction within 48 hours of surgery
Left ventricular ejection fraction of \< 35%
Any concomitant cardiac or non-cardiac procedure
Previous cardiac surgery
Preoperative severe end-organ dysfunction (dialysis, liver failure, respiratory failure), cancer or any co-morbidity that reduce life expectancy to less than 5 years.
Inability to use the saphenous vein or to use both radial and right internal thoracic arteries
Anticipated need for coronary thrombo-endarterectomy
Planned hybrid revascularization

What this trial measures

  • Composite Outcome> 72 hours after surgery and/or repeat revascularization

    A composite of death from any cause, any stroke, post discharge myocardial infarction and/or repeat revascularization.