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Study of Adenosine and Verapamil for Premature Ventricular Contractions (PVCs)

This study is looking at how two medications, Adenosine and Verapamil, affect premature ventricular contractions (PVCs). PVCs are extra heartbeats that start in the lower chambers of your heart. Researchers want to see if Adenosine, given as an IV infusion, or Verapamil, also given as an IV, can reduce your PVCs. They will measure this using an electrocardiogram (EKG), which records your heart's electrical activity. You might be able to join if you are between 18 and 70 years old, have PVCs, and are already scheduled for a heart procedure called an electrophysiology study with cardiac ablation. The study is currently unclear on its recruitment status, but aims to enroll 100 participants. The goal is to better understand what causes PVCs, which could lead to new treatments.

Study design
This is an unblinded, controlled study that is not randomized, meaning participants are not assigned to groups by chance. It aims to enroll 100 participants.
What's involved
You would receive Adenosine and/or Verapamil after catheters are placed during your scheduled electrophysiology study. Your PVCs will be measured by EKG at baseline.
Compensation
Not stated in the trial record.
Follow-up
Your PVCs will be measured at baseline, but no further follow-up time is specified.

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NCT03218137

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Recruiting
PHASE4Ages 18–70InterventionalDiagnostic
Weill Medical College of Cornell University
~100 participants
Updated 2026-06-23 on ClinicalTrials.gov
What's tested:Adenosine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effects of Adenosine on premature ventricular contractions (PVCs) as measured by EKG;
Measured over baseline
+1 more outcome measured

Conditions

Premature Ventricular Contraction (PVC)

Explore related trials

Ventricular premature complex

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • James E Ip, M.D · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

Who to contact

James E Ip, M.D
[email protected]
212 746 2158
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of premature ventricular contractions (PVCs)
Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs
Male or female between the ages of 18 and 70 years
Capable of giving informed consent

Exclusion

Any structural heart disease
Coronary artery disease (≥ 70% stenosis)
Current treatment with anti-arrhythmic drugs
Pregnant
Asthma (if administering adenosine)

What this trial measures

  • Effects of Adenosine on premature ventricular contractions (PVCs) as measured by EKG;baseline

    The metrics that will be collected will be: * Baseline frequency of premature ventricular contractions (PVCs) * Frequency of premature ventricular contractions (PVCs) during adenosine administration

  • Effects of verapamil on premature ventricular contractions (PVCs) as measured by EKGs.baseline

    The metrics that will be collected will be: * Baseline frequency of premature ventricular contractions (PVCs) * Frequency of premature ventricular contractions (PVCs) during verapamil administration