This observational study aims to understand how muscle protein (the building blocks of muscle) is made and broken down in people with cirrhosis (severe liver scarring). Researchers will use special tracer methods, involving blood draws and a single muscle biopsy (a small tissue sample), to measure these processes. The goal is to find out why people with cirrhosis often lose muscle. You might be able to join if you have cirrhosis with a Child-Pugh score of A5-B7, or if you are a healthy control with normal liver enzyme levels. You cannot participate if you have diabetes, cancer, kidney failure, are pregnant, or recently had surgery. The study will measure how quickly muscle protein is made over 4 hours.

Study design

This is an observational study with a planned enrollment of 20 participants. It includes both people with cirrhosis and healthy volunteers.

What's involved

You will have two venous catheters inserted for blood draws and injections. Following these, you will have a single muscle biopsy taken from your thigh.

Compensation

Not stated in the trial record.

Follow-up

The primary measurement for the study is taken at 4 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.