This observational study aims to understand why some people with occasional headaches develop chronic daily or near-daily headaches, including chronic migraine. Researchers want to find differences in brain structure and function, spinal fluid, blood, genetics, and patient characteristics that might explain this process. The study is looking for 700 participants, including those with any type of headache and those with very few headaches. There are no specific interventions (treatments) being tested. Success for this study means identifying factors that predict whether headaches will become chronic over a five-year period. The current recruitment status is unclear.

Study design

This is an observational study aiming to enroll 700 participants. It is not testing a specific drug or treatment.

What's involved

You would complete online questionnaires, provide a blood sample, and undergo a magnetic resonance imaging (MRI) scan without contrast. You may also choose to have a lumbar puncture (spinal tap).

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, prediction of headache chronification, is measured at five years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.