Preventing Eye Infection After Cataract Surgery

This study is looking at whether an antibiotic called moxifloxacin, given as an injection into your eye (intracameral injection) after cataract surgery, can help prevent a serious eye infection called endophthalmitis. You would receive either moxifloxacin or a placebo (an inactive substance). The study is open to people aged 40 and older who have cataracts that affect their vision. You cannot join if you are allergic to certain antibiotics (fluoroquinolones) or vitamin B12. The main goal is to see if there's a difference in how many people get endophthalmitis after surgery. The current status of this study is unclear.

Study design
This interventional study plans to enroll 60,000 participants. You would receive either moxifloxacin or a placebo after cataract surgery.
What's involved
You would have eye examinations one day, one week, and one month after your surgery.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for one month after your surgery.

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NCT03244072

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery

Not Yet Recruiting
PHASE2Ages 40+InterventionalPrevention
Jason Ahee, M.D.
~60,000 participants
Updated 2025-09-25 on ClinicalTrials.gov
What's tested:MoxifloxacinPlacebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Endophthalmitis after cataract surgery
Measured over Subjects will undergo eye examinations at one day, one week, and one month post-operatively
Endophthalmitis
1 sites across 1 states
Utah1
  • Jason Ahee, M.D. · PRINCIPAL_INVESTIGATOR · Zion Therapeutics, LLC

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Eligibility criteria

Inclusion

visually significant cataracts

Exclusion

allergy to fluoroquinolones, cobalamin (B12)
  • Endophthalmitis after cataract surgerySubjects will undergo eye examinations at one day, one week, and one month post-operatively

    Subjects will be followed after cataract surgery and have post-operative eye examinations to determine if infection in the eye (endophthalmitis) occurs during the study period.