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Observational Study: Mapping Disease Pathways for Biliary Atresia

This observational study aims to understand the genetic causes of Biliary Atresia (BA), a serious liver condition in babies that often requires a liver transplant. Researchers will look at the genetic makeup of people with BA to find out what pathways are involved in the disease. The study is trying to understand if there are genetic differences between the 'isolated' form of BA, thought to be caused by viruses, and the 'syndromic' form, which is linked to other birth defects. The goal is to identify the genomic pathways of BA. You may be able to join if you have Biliary Atresia and have received or are about to receive a liver transplant at one of the participating hospitals: Children's Hospital of Pittsburgh, Kings College Hospital, Children's Hospital of Birmingham, or Hospital Sírio-Libanês. The study is currently unclear on its recruitment status.

Study design
This is an observational study planning to include 1100 participants. It is not testing a specific treatment.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The genomic pathways of BA will be measured for up to two years.

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NCT03273049

Mapping Disease Pathways for Biliary Atresia

Recruiting
Not specifiedAll AgesObservational
University of Pittsburgh
~1,100 participants
Updated 2026-08-10 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Genomic pathways of BA
Measured over up to two years

Conditions

Biliary Atresia

Explore related trials

Biliary Atresia

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

Morgan L Paul, BSN
[email protected]
4126928472
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Eligibility criteria

Inclusion

living individuals who were diagnosed with Biliary Atresia and received or are about to receive a liver transplant from multiple participating centers (Children's Hospital of Pittsburgh, Kings College Hospital, Children's Hospital of Birmingham, and Hospital Sírio-Libanês).

Exclusion

No child participant in the care of the state will be enrolled, nor will patients in the care of temporary or informal guardians be enrolled

What this trial measures

  • Genomic pathways of BAup to two years

    Main project outcome will consist of pathways comprising multiple susceptibility genes involved in morphogenesis of the liver and other organs, which explain the complex phenotype of BA.