Binocular Games for Amblyopia Treatment

This study is testing a new way to treat amblyopia (sometimes called "lazy eye") in children aged 4 to 10 years old. It uses binocular games played on a tablet, where one eye sees reduced contrast and the other sees high contrast. The goal is to see if these games can help improve vision more completely and for a longer time compared to current methods. We expect about 40% of children to achieve normal vision within 8 weeks. If your child has amblyopia due to strabismus (crossed eyes), anisometropia (different prescriptions in each eye), or a combination, and meets certain vision requirements, they may be able to join. The study is currently unclear on its recruitment status.

Study design
This study is an interventional, randomized controlled trial with three groups, aiming to enroll 120 participants.
What's involved
Participants will play binocular games on a tablet for 1 hour per day, 5 days per week, for 8 weeks. Visual acuity will be measured at the beginning and after 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
Visual acuity is measured at 8 weeks. Children with good vision at 8 weeks will have 4 weeks of stereoacuity training, and those with remaining amblyopia will have 4 weeks of dichoptic movie treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03288948

Binocular Amblyopia Treatment

Recruiting
NAAges 4–10InterventionalTreatment
Retina Foundation of the Southwest
~120 participants
Updated 2026-02-23 on ClinicalTrials.gov
What's tested:Binocular games for treatment of amblyopia

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in visual acuity of the amblyopic eye
Measured over baseline vs 8 weeks
Amblyopia
1 sites across 1 states
Texas1

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Eligibility criteria

Inclusion

age 4-10 y
male and female
strabismic, anisometropic, or combined mechanism amblyopia
amblyopic eye best-corrected visual acuity 0.3-0.8 logMAR
fellow eye best-corrected visual acuity ≤0.1 logMAR
interocular visual acuity difference ≥0.3 logMAR
wearing glasses (if needed) for 8 weeks or no change visual acuity with glasses at 2 visits
4 weeks apart.
child's ophthalmologist and family must be willing to forgo patching treatment during the 12-week study period
parent's informed consent
child must demonstrate understanding and ability to play binocular games

Exclusion

prematurity ≥8 weeks
coexisting ocular or systemic disease
developmental delay
strabismus \>5pd
any binocular amblyopia treatment in the past 3 months
  • Change in visual acuity of the amblyopic eyebaseline vs 8 weeks

    ATS-HOTV for age 4-6.9 years or E-ETDRS for age 7-10.9 years