CPAP for Supine Hypertension in Autonomic Failure

This study is looking at whether continuous positive airway pressure (CPAP) can help lower high blood pressure (supine hypertension) in people with autonomic failure. Supine hypertension is a common problem in autonomic failure, where blood pressure gets too high when lying down. CPAP is a device that uses mild air pressure to keep airways open, often used for sleep-related breathing issues. Researchers want to see if using CPAP at night can reduce your blood pressure. To join, you need to be between 18 and 85 years old, have autonomic failure and supine hypertension, and not have certain other health conditions like heart failure or serious allergies. The main goal is to measure your supine systolic blood pressure after 12 hours of CPAP use. The study is currently unclear on its recruitment status and plans to enroll 12 participants.

Study design
This is an interventional study planning to enroll 12 participants. It will test continuous positive airway pressure (CPAP) against a placebo.
What's involved
You would use a CPAP device during the night, starting at 8 PM. The CPAP level will be determined during an initial test.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, supine systolic blood pressure, is measured at 12 hours.

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NCT03312556

Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Recruiting
NAAges 18–85InterventionalTreatment
Vanderbilt University Medical Center
~12 participants
Updated 2025-11-06 on ClinicalTrials.gov
What's tested:continuous positive airway pressure (CPAP)Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Supine Systolic Blood Pressure
Measured over 12 hours
Supine Hypertension
Autonomic Failure
1 sites across 1 states
Tennessee1
  • Italo Biaggioni, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center

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Eligibility criteria

Inclusion

Patients with autonomic failure and with supine hypertension from all races

Exclusion

All medical students
Pregnant women
High-risk patients (e.g. heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)
History of serious allergies or asthma.
  • Supine Systolic Blood Pressure12 hours

    change in supine systolic blood pressure from baseline