Understanding Progressive Apraxia of Speech

This observational study aims to better understand and tell apart two different kinds of Progressive Apraxia of Speech (AOS). AOS is a problem with planning speech that gets worse over time. Researchers want to see if these different types of AOS can be identified through brain imaging and other tests. To join, you must be over 18, speak English, and have a progressive speech problem that a speech-language pathologist has identified as AOS. You will have a neurological exam, speech and language assessments, memory and thinking tests, an MRI brain scan, and a DaTscan. The study hopes to distinguish these AOS types within 1-2 years after your initial imaging. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 47 participants. It does not involve a specific treatment or drug.
What's involved
You would see a neurologist, a speech pathologist, and a study coordinator for various tests. You would also undergo an MRI brain scan and a DaTscan.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is measured 1-2 years after baseline imaging, suggesting a follow-up period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03313011

The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~47 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Testing protocol for the study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Distinguish types of Progressive Apraxia of Speech
Measured over 1-2 years after baseline imaging
Apraxia of Speech
Non-fluent Aphasia
Primary Progressive Aphasia
Primary Progressive Nonfluent Aphasia
1 sites across 1 states
Minnesota1
  • Keith Josephs, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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  • Distinguish types of Progressive Apraxia of Speech1-2 years after baseline imaging

    Distinguish types of PAOS using the Apraxia of Speech Rating Scale (ASRS)