Improving Measurement and Treatment of Post-stroke Neglect

This study is looking at better ways to measure and treat neglect, a common problem after a stroke where people have difficulty paying attention to one side of their body or space. Researchers are testing a new approach that combines non-invasive brain stimulation called transcranial direct current stimulation (tDCS) with arm and hand exercises. They want to see how this combination affects brain activity, arm movement, and attention in people who have had a stroke at least 3 months ago. You might be able to join if you are an adult who has had an ischemic or hemorrhagic stroke, have certain scores on arm movement tests, and show signs of neglect. The study aims to see if this intervention can improve brain excitability, motor skills, and attention. The current status of the study is unclear.

Study design
This is an interventional study with a planned enrollment of 17 participants. It compares active tDCS with sham tDCS, where electrodes are placed but no direct current is delivered.
What's involved
Participants will be assessed at the beginning of the study and again 30 minutes later. The intervention involves 30 minutes of tDCS combined with repetitive task-specific practice for the arm/hand.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed at baseline and 30 minutes later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03317860

Improving Measurement and Treatment of Post-stroke Neglect

Recruiting
NAAges 18+Interventional
VA Office of Research and Development
~17 participants
Updated 2026-09-04 on ClinicalTrials.gov
What's tested:Sham transcranial direct current stimulation (tDCS)Active direct current stimulation (tDCS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in excitability of fronto-parietal connectivity
Measured over Participants will be assessed at baseline and 30 minutes later
Stroke

NCT03317860

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Emily S. Grattan, PhD MS BS · PRINCIPAL_INVESTIGATOR · VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

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Eligibility criteria

Inclusion

Ischemic or hemorrhagic stroke 3 months post stroke
Fugl-Meyer Upper Extremity (FMA-Upper Extremity) score between 20-56/60
Inducible motor evoked potential (MEP) of the abductor pollicis brevis (APB) on the paretic stimulation (TMS)
Demonstrate the presence of unilateral neglect (Virtual Reality Lateralized Attention Test score \<18)

Exclusion

History of cortical hemorrhagic stroke
Presence of any MRI, TMS, tDCS risk factors including:
history of seizures
history of brain tumor
hardware in skull or spine (e.g. coils, clips)
implantable medical device (e.g. pacemaker)
metal in body (not compatible with MRI)
pregnancy
Severe spasticity (Modified Ashworth Scale score 3)
Severe aphasia or cognitive impairment limiting participants' comprehension (National Institutes of Health Stroke Scale Level of Consciousness Commands Item score 1 or Best Language Item score 2)
Unable to travel to UE Motor Function Laboratory at the Center for Rehabilitation Research in Neurological Conditions (a collaborative, Memorandum of Understanding (MOU) approved, research center Ralph H. Johnson VA Medical Center and the Medical University of South Carolina) for the study
  • Change in excitability of fronto-parietal connectivityParticipants will be assessed at baseline and 30 minutes later

    Excitability of fronto-parietal connectivity measured by paired pulse twin coil transcranial magnetic stimulation (TMS) test. In each session, the difference in excitability of fronto-parietal connectivity between pre and post stimulation will be measured.