Study of Immune Responses to Influenza Vaccination

This study aims to better understand how your body's immune system responds to the influenza (flu) vaccine. Researchers are looking for 75 community-dwelling adults who need a standard flu shot. You will receive one intramuscular (into the muscle) dose of seasonal quadrivalent inactivated influenza vaccine. To see if the vaccine is successful, researchers will measure your influenza neutralizing antibody titers (levels of protective antibodies) between 21 and 42 days after vaccination. You cannot join if you have a fever, active cancer, are taking immunosuppressing medications, have donated blood recently, or have been vaccinated for flu in the past 6 months. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 75 participants. The phase of the study is not specified.
What's involved
You will receive one influenza vaccination. You will also have peripheral blood drawn at pre-defined intervals to study lymphocyte responses.
Compensation
Not stated in the trial record.
Follow-up
Your influenza neutralizing antibody titers will be measured between 21 and 42 days after vaccination.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03346772

Study of Immune Responses to Influenza Vaccination

Completed
PHASE4Ages 18+InterventionalBasic science
University of Pennsylvania
~150 participants
Updated 2026-08-27 on ClinicalTrials.gov
What's tested:Influenza vaccination

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Influenza neutralizing antibody titers
Measured over 21-42 days
Influenza Vaccination
1 sites across 1 states
Pennsylvania1
  • E.John Wherry, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Community-dwelling adults able to provide consent who need influenza vaccination for standard of care

Exclusion

febrile illness at time of vaccination
active malignancy
use of immunosuppressing medications
blood donation in the past 60 days
influenza vaccinated during the preceding 6 months
allergic reactions to influenza vaccination
  • Influenza neutralizing antibody titers21-42 days