NCT03359109
Metallosis on Tissues and Serum Metal Levels in Children
Enrolling by Invitation
Not specifiedAges 4–18ObservationalMayo ClinicInvestigator-initiated
~50 participants
Updated 2025-11-04 on ClinicalTrials.gov
At a glance
Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mechanistic responses of bone repair cells upon Ti exposure
Measured over 3-6 months
Conditions
Where it's being run
2 sites across 2 statesMinnesota1
South Dakota1
Study leadership
- A.Noelle Larson, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Ages 4 years - 18 years
Stainless steel, titanium or titanium-alloy based implants, scheduled for surgery
De novo surgery where titanium implant placement
Exclusion
Concomitant infection
What this trial measures
- Mechanistic responses of bone repair cells upon Ti exposure3-6 months
To address how deregulated bone repair provokes adverse reactions, the investigators will monitor gene regulatory effects in cell culture models of titanium exposure by either silencing or activating key biological pathways