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Pilot Study of Glutamine Use in Bone Marrow Plasma Cells

This pilot study aims to understand how normal bone marrow plasma cells use glutamine (a type of amino acid). Researchers will give participants an intravenous (IV) infusion of 5-13C-Glutamine and then take a bone marrow aspiration (a procedure to collect a small sample of bone marrow). The main goal is to measure the amount of 13-Carbon molecules in the plasma cells' TCA cycle (a process cells use to create energy) to see how glutamine is being used. This study is looking for 20 healthy volunteers between 18 and 60 years old. You cannot participate if you have kidney or liver disease, are pregnant, use steroids, have anemia, or have a high BMI. The study is currently recruiting participants.

Study design
This is an interventional pilot study with 20 healthy adult participants, divided into two groups of 10 volunteers each.
What's involved
You would receive an intravenous infusion of 5-13C-Glutamine and undergo a bone marrow aspiration. The primary measurement is taken around 1 hour after the intervention.
Compensation
Not stated in the trial record.
Follow-up
The primary measurement is taken through study completion, an average of 1 hour after the intervention.

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NCT03384108

In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

Recruiting
NAAges 18–60InterventionalDiagnostic
Mayo Clinic
~20 participants
Updated 2026-02-25 on ClinicalTrials.gov
What's tested:5-13C-GlutamineBone marrow aspiration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of enrichment of 13-Carbon molecules in the TCA cycle metabolites of plasma cells measured by gas chromatography mass spectrometry.
Measured over Through study completion, an average of 1 hour

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Wilson Gonsalves, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Wilson Gonsalves
[email protected]
5072842511
Email the study team

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Eligibility criteria

Inclusion

Ages 18-60
Able to provide written consent

Exclusion

Renal Failure
Pregnancy
Active steroid use
Active liver Disease
Anemia (Hemoglobin \< 12.5 g/dL in men and \< 11.5 g/dL in women)
H/O alcohol use (average \> 2 drinks per day)
BMI \> 30

What this trial measures

  • Percentage of enrichment of 13-Carbon molecules in the TCA cycle metabolites of plasma cells measured by gas chromatography mass spectrometry.Through study completion, an average of 1 hour

    The plasma cells obtained from the bone marrow aspiration will be processed to determine the percent of 13-carbon enrichment in the various molecules of the TCA cycle within the plasma cells. The outcomes will be reported as a percentage. E.G. 5% of glutamine is labeled with 13-Carbon; e.g. 4% of glutamate is labeled with 13-carbon etc.