Panitumumab-IRDye800 for Pancreatic Cancer Surgery

This study is looking at a new way to help surgeons see pancreatic cancer more clearly during surgery. It uses a drug called panitumumab-IRDye800, which combines an antibody drug (panitumumab) with a special dye (IRDye800CW) that can be seen with a special camera. The goal is to see if this combination makes cancer cells light up, making them easier to find and remove. You might be able to join if you have pancreatic adenocarcinoma, are planning to have surgery to remove the cancer, and are generally healthy enough for surgery. The main goal is to find the best dose of panitumumab-IRDye800 to make the tumor stand out from healthy tissue. This study is currently recruiting about 27 participants.

Study design
This is a Phase I/II interventional study that will enroll about 27 participants. It involves a dose-escalation phase to find the optimal dose.
What's involved
You would receive panitumumab and then panitumumab-IRDye800 intravenously (IV). Surgery would then take place 2-5 days later, involving special imaging during the procedure.
Compensation
Not stated in the trial record.
Follow-up
You will be followed up at 15 and 30 days after completing the study treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03384238

Panitumumab-IRDye800 in Patients With Pancreatic Cancer Undergoing Surgery

Recruiting
PHASE1Ages 19+InterventionalDiagnostic
George Poultsides
~27 participants
Updated 2026-03-17 on ClinicalTrials.gov
What's tested:Fluorescence ImagingPanitumumabPanitumumab-IRDye800

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tumor to background ratio (TBR)
Measured over 1 day
Pancreatic Adenocarcinoma

NCT03384238

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Stanford University, School of Medicine

    Palo Alto, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • George Poultsides · PRINCIPAL_INVESTIGATOR · Stanford University

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Eligibility criteria

Inclusion

Clinically suspected or biopsy-confirmed diagnosis of pancreatic adenocarcinoma
Planned standard of care surgery with curative intent for pancreatic adenocarcinoma
Life expectancy of more than 12 weeks
Karnofsky performance status of at least 70% or Eastern Cooperative Oncology Group (ECOG)/Zubrod level =\< 1
Hemoglobin \>= 9 gm/dL
Platelet count \>= 100,000/mm\^3
Magnesium \> the lower limit of normal per institution normal lab values
Potassium \> the lower limit of normal per institution normal lab values
Calcium \> the lower limit of normal per institution normal lab values
Thyroid-stimulating hormone (TSH) \< 13 micro international units/mL

Exclusion

Received an investigational drug within 30 days prior to first dose of panitumumab-IRDye800
Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); or unstable angina within 6 months prior to enrollment
History of infusion reactions to panitumumab or other monoclonal antibody therapies
Pregnant or breastfeeding
Evidence of corrected QT (QTc) prolongation on pretreatment electrocardiography (ECG) (greater than 440 ms in males or greater than 460 ms in females)
Lab values that in the opinion of the physician would prevent surgical resection
Patients receiving class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents
  • Tumor to background ratio (TBR)1 day

    TBR is defined as fluorescence intensity of tumor tissue compared to that of normal surrounding pancreatic tissue.