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NCT03398304

Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study

Enrolling by Invitation
NAAges 18–49InterventionalBasic science
Vanderbilt University Medical Center
~35 participants
Updated 2026-05-15 on ClinicalTrials.gov
What's tested:Graded ExerciseMarathon participation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change of fibrinolysis (mg/ml) before graded exercise/marathon participation and after graded exercise/marathon participation (physiological parameter)
Measured over Baseline to post-exercise/marathon (within 3 hours of exercise/marathon completion)
+2 more outcomes measured

Conditions

Acute Phase Response

Explore related trials

Acute-Phase Reaction

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Jonathan Schoenecker, MD, PhD · PRINCIPAL_INVESTIGATOR · Vanderbilt Orthopaedics

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy individuals (male or female) aged 18-29
Regular participation (at least 2 times per week) in moderate intensity exercise
BMI between 18.5 and 30.0
Healthy individuals (male or female) aged 18-49
In training to complete a marathon (individuals already planning on running a marathon and training accordingly for it)
BMI between 18.5 and 30.0

Exclusion

Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
Acute disease process such as an infection, broken bone, or asthma attack
Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
Pregnant women
Recent inpatient admission within the last six months
History of smoking or illicit drug use
Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
Acute disease process such as an infection, broken bone, or asthma attack
Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
Pregnant women
Recent inpatient admission within the last six months
History of smoking or illicit drug use

What this trial measures

  • Change of fibrinolysis (mg/ml) before graded exercise/marathon participation and after graded exercise/marathon participation (physiological parameter)Baseline to post-exercise/marathon (within 3 hours of exercise/marathon completion)

    To measure the acute phase response fibrinolysis, plasminogen consumption, and inflammatory profiles of healthy individuals before and after graded exercise (at rest, light intensity, and medium intensity) and following endurance running, as defined by changes in fibrinolysis, plasminogen consumption, and inflammatory response.

  • Change of plasminogen (mg/ml) consumption before graded exercise/marathon participation and after graded exercise/marathon participation (physiological parameter)Baseline to post-exercise/marathon (within 3 hours of exercise/marathon completion)

    To measure the acute phase response fibrinolysis, plasminogen consumption, and inflammatory profiles of healthy individuals before and after graded exercise (at rest, light intensity, and medium intensity) and following endurance running, as defined by changes in fibrinolysis, plasminogen consumption, and inflammatory response.

  • Change of inflammatory response (mg/ml) before graded exercise/marathon participation and after graded exercise/marathon participation (physiological parameter)Baseline to post-exercise/marathon (within 3 hours of exercise/marathon completion)

    To measure the acute phase response fibrinolysis, plasminogen consumption, and inflammatory profiles of healthy individuals before and after graded exercise (at rest, light intensity, and medium intensity) and following endurance running, as defined by changes in fibrinolysis, plasminogen consumption, and inflammatory response.