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NCT03407833

Physiologic and Functional Adaptations of Insulin Sensitive Tissues

Enrolling by Invitation
Not specifiedAges 18+Observational
Vanderbilt University Medical Center
~500 participants
Updated 2025-12-18 on ClinicalTrials.gov
What's tested:Endoscopy biopsySurgical biopsyMixed-meal tolerance testExcised Liver Tissue Sampling

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ability to establish organoid cultures
Measured over 12 months

Conditions

Diabetes
Insulin Resistance
Obesity
Bariatric Surgery Candidate
Roux-en-y Gastric Bypass
Liver Diseases

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NCT03407833

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Vanderbilt University Medical Center

    Nashville, Tennesseeno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Charles Flynn, Ph.D. · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Exclusion

Known history of intestinal diseases including, but not limited to, inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease) and celiac sprue.
Smoking \>7 cigarettes per day
Malabsorptive syndromes
Pregnant or breastfeeding
Recent history of malignancy (\<5 years ago)
Previous lap band surgery
Established renal disease
Previous lap band, sleeve gastrectomy, or gastric bypass surgery
Recent history of malignancy (\< 5 years ago)
Established organ dysfunction
Previous lap band, sleeve gastrectomy, or gastric bypass surgery
Alpha 1 anti-trypsin disease, Wilson's disease, viral hepatitis, alcoholic liver disease

What this trial measures

  • Ability to establish organoid cultures12 months

    Measure percent success rate of making organoid cultures from tissue biopsies