NCT03417856
Defining the Skin and Blood Biomarkers of Ichthyosis
Enrolling by Invitation
Not specifiedAges 1–60ObservationalNorthwestern UniversityInvestigator-initiated
~200 participants
Updated 2026-04-27 on ClinicalTrials.gov
At a glance
Recruiting sites
0 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cellular infiltrates
Measured over One year
+1 more outcome measured
Conditions
Where it's being run
4 sites across 2 statesIllinois3
New York1
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Control and ichthyosis subjects may be of either sex and must be between 1-60 years of age at the time of enrollment
Ichthyosis subjects include individuals with a diagnosis Netherton syndrome, lamellar ichthyosis, or other ichthyosis subtypes
Ichthyosis subjects should not have administered systemic immunosuppressant therapy in the month before the study
Ichthyosis subjects should not use topical immunosuppressants in the week before the study
Ichthyosis subjects should not have applied emollients to the planned biopsy sites within 12 hours before biopsy, but can be applied elsewhere
Controls may have no inflammatory disease, atopy, or obvious xerosis (urticaria, food allergy, allergic rhinitis or conjunctivitis, asthma)
Controls for skin sampling may have no observable abnormality in the sampled skin and, to further assure the normality of the "normal" skin edges, must not have evidence of inflammation or epidermal change in the lesion to be surgically removed
Subjects and guardians of minors must sign the approved IRB consent form(s) prior to initiation of the study protocol
Subjects whose main diagnosis is deemed unsafe by the study investigator for study participation
Exclusion
Subjects who are unable to give informed consent or assent
What this trial measures
- Cellular infiltratesOne year
We will examine your skin and blood samples for various immune cells known to be involved in ichthyosis.
- Gene expressionOne year
We will examine your skin and blood samples for various genes known to contribute to ichthyosis by analyzing RNA and cytokines.