Observational Study of Anesthetics and Pain Medications in Children
This study is looking at how common pain medications and anesthetics (drugs used to put people to sleep for surgery) affect children and teenagers. Researchers want to understand how these drugs, such as Ketorolac Tromethamine, Hydromorphone, Ketamine, Oxycodone, and Morphine, are processed by the body and what their side effects are. You could join if you are between 0 and 17 years old and your doctor has prescribed one of these medications as part of your usual care. The study will measure how quickly the drug leaves your body and how it's distributed. This is an observational study, meaning the drugs are given as part of your standard medical care, not specifically for the study. The study aims to enroll 500 participants.
- Study design
- This is an observational study, meaning treatments are given as part of standard medical care, not specifically for the study. It aims to enroll 500 participants.
- What's involved
- You would have blood samples taken (up to 5 samples over 10 to 48 hours) at specific times after receiving your prescribed medication. Researchers will also review your medical records, vital signs, and ask questions.
- Compensation
- Not stated in the trial record.
- Follow-up
- Blood samples will be collected for up to 48 hours after the drug dose to measure how the drug is processed by the body.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Anesthetics and Analgesics in Children
At a glance
Conditions
Where it's being run
13 sites across 11 statesStudy leadership
- Chi Hornik, PharmD · PRINCIPAL_INVESTIGATOR · Duke Clinical Research Institute
Who to contact
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What this trial measures
- Clearance (CL) or apparent oral clearance (CL/F)up to 48 hours post dose
- Volume of distribution (V) or apparent oral volume of distribution (V/F)up to 48 hours post dose
- Elimination rate constant (ke)up to 48 hrs post dose
- Half-life (t1/2)up to 48 hrs post dose
- Absorption rate constant (ka)up to 48 hrs post dose
- Area under the curve (AUC)up to 48 hrs post dose
- Maximum concentration (CMAX)up to 48 hrs post dose
- Time to achieve maximum concentration (TMAX)up to 48 hrs post dose