Observational Study of Anesthetics and Pain Medications in Children

This study is looking at how common pain medications and anesthetics (drugs used to put people to sleep for surgery) affect children and teenagers. Researchers want to understand how these drugs, such as Ketorolac Tromethamine, Hydromorphone, Ketamine, Oxycodone, and Morphine, are processed by the body and what their side effects are. You could join if you are between 0 and 17 years old and your doctor has prescribed one of these medications as part of your usual care. The study will measure how quickly the drug leaves your body and how it's distributed. This is an observational study, meaning the drugs are given as part of your standard medical care, not specifically for the study. The study aims to enroll 500 participants.

Study design
This is an observational study, meaning treatments are given as part of standard medical care, not specifically for the study. It aims to enroll 500 participants.
What's involved
You would have blood samples taken (up to 5 samples over 10 to 48 hours) at specific times after receiving your prescribed medication. Researchers will also review your medical records, vital signs, and ask questions.
Compensation
Not stated in the trial record.
Follow-up
Blood samples will be collected for up to 48 hours after the drug dose to measure how the drug is processed by the body.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03427736

Anesthetics and Analgesics in Children

Recruiting
Not specifiedAges 0–17Observational
Chi Dang Hornik
~551 participants
Updated 2026-08-05 on ClinicalTrials.gov
What's tested:Ketorolac TromethamineHydromorphoneKetamineOxycodoneMorphine

At a glance

Recruiting sites
5 of 13 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clearance (CL) or apparent oral clearance (CL/F)
Measured over up to 48 hours post dose
+7 more outcomes measured
Anesthesia
Pain
13 sites across 11 states
Missouri2
Texas2
California1
Colorado1
Delaware1
Illinois1
North Carolina1
Oregon1
  • Chi Hornik, PharmD · PRINCIPAL_INVESTIGATOR · Duke Clinical Research Institute

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  • Clearance (CL) or apparent oral clearance (CL/F)up to 48 hours post dose
  • Volume of distribution (V) or apparent oral volume of distribution (V/F)up to 48 hours post dose
  • Elimination rate constant (ke)up to 48 hrs post dose
  • Half-life (t1/2)up to 48 hrs post dose
  • Absorption rate constant (ka)up to 48 hrs post dose
  • Area under the curve (AUC)up to 48 hrs post dose
  • Maximum concentration (CMAX)up to 48 hrs post dose
  • Time to achieve maximum concentration (TMAX)up to 48 hrs post dose