Vasopressin and Pain Perception in the Brain

This study is looking at how a substance called vasopressin, given as a nasal spray, affects how your brain processes pain. Researchers want to understand if vasopressin can influence how you experience pain, especially after watching someone else experience pain relief. They will use a special type of MRI scan called fMRI (functional magnetic resonance imaging) to see brain activity. To be eligible, you need to be between 18 and 55 years old and speak English. The study aims to see if vasopressin changes brain signals in a specific area (Supplementary Motor Area) during painful stimulation.

Study design
This is an interventional study planning to enroll 56 participants. You would be randomly assigned to receive either intranasal vasopressin or a saline placebo, and both you and the researchers would not know which you received.
What's involved
You would receive intranasal vasopressin or saline before an fMRI experiment, which involves brain scans. You would also watch a video about someone experiencing pain relief.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, measuring brain signal changes, is taken on Day 2 during painful stimulations.

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NCT03446456

Vasopressin and Pain Perception in the Brain

Recruiting
PHASE1Ages 18–65InterventionalBasic science
University of Maryland, Baltimore
~56 participants
Updated 2026-07-09 on ClinicalTrials.gov
What's tested:Arginine vasopressinSalineObservational learningfMRI data aquisition

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful Stimulation
Measured over Day 2, the average of 24 trials of painful stimulations with each stimulation lasting 20 seconds
Acute Pain
1 sites across 1 states
Maryland1
  • Luana Colloca, MD/PHD/MS · PRINCIPAL_INVESTIGATOR · University of Maryland Baltimore School of Nursing

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Eligibility criteria

Inclusion

Age ( 18-55 years old)
English speaker (written and spoken)

Exclusion

Cardiovascular, neurological diseases, pulmonary abnormalities, kidney disease, liver disease, degenerative neuromuscular disease, history of cancer within past 3 years
Any history of chronic pain disorder or currently in pain
Severe psychiatric condition (e.g. schizophrenia, bipolar disorders, mania, autism) and /or psychiatric condition leading to treatment and/or hospitalization within the last 3 years.
Family (first degree) history of mania, schizophrenia, or other psychoses
Lifetime alcohol/drug dependence or alcohol/drug abuse in past 3 months
Pregnancy or breast feeding
Color-blindness
Impaired, uncorrected hearing
History of angioedema
High blood pressure (above 140 mmHg) or symptomatic low blood pressure
History of fainting
Left handed
Allergies or sensitivities to creams, lotions or food coloring
Any non-organic implant or any non-removable metal device (e.g. pacemaker, cochlear implants, stents, surgical clips, non-removable piercings)
Any prior eye injury or the potential of a foreign body in the eye (e.g. worked in metal fields)Persisting functional impairment due to a head trauma
Fear of closed spaces
Any other contraindications for MRI (e.g. large tattoos on head and neck)
Previously participated in a "Pain Perception in the Brain" Study
Failed drug test (testing for opiates, cocaine, methamphetamines, amphetamines and THC)
  • Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful StimulationDay 2, the average of 24 trials of painful stimulations with each stimulation lasting 20 seconds

    Blood oxygenation level dependent (BOLD) responses will allow the identification of relative activation/deactivation in the brain as a result of events (e.g. painful stimulations) that will be given during the experiment. Changes in the Percentage of BOLD signal are calculated as the BOLD signal in the right supplementary motor area during the 20-second heat pain divided by the whole-brain average BOLD signal during that 20-second heat pain.