Vasopressin and Pain Perception in the Brain
This study is looking at how a substance called vasopressin, given as a nasal spray, affects how your brain processes pain. Researchers want to understand if vasopressin can influence how you experience pain, especially after watching someone else experience pain relief. They will use a special type of MRI scan called fMRI (functional magnetic resonance imaging) to see brain activity. To be eligible, you need to be between 18 and 55 years old and speak English. The study aims to see if vasopressin changes brain signals in a specific area (Supplementary Motor Area) during painful stimulation.
- Study design
- This is an interventional study planning to enroll 56 participants. You would be randomly assigned to receive either intranasal vasopressin or a saline placebo, and both you and the researchers would not know which you received.
- What's involved
- You would receive intranasal vasopressin or saline before an fMRI experiment, which involves brain scans. You would also watch a video about someone experiencing pain relief.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, measuring brain signal changes, is taken on Day 2 during painful stimulations.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Vasopressin and Pain Perception in the Brain
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Luana Colloca, MD/PHD/MS · PRINCIPAL_INVESTIGATOR · University of Maryland Baltimore School of Nursing
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful StimulationDay 2, the average of 24 trials of painful stimulations with each stimulation lasting 20 seconds
Blood oxygenation level dependent (BOLD) responses will allow the identification of relative activation/deactivation in the brain as a result of events (e.g. painful stimulations) that will be given during the experiment. Changes in the Percentage of BOLD signal are calculated as the BOLD signal in the right supplementary motor area during the 20-second heat pain divided by the whole-brain average BOLD signal during that 20-second heat pain.