SYNERGY-AI: Artificial Intelligence for Cancer Clinical Trial Matching

This study is an international registry exploring how an Artificial Intelligence (AI) tool can help match cancer patients to clinical trials. The AI tool, called SYNERGY-AI, uses your existing electronic health records to find suitable trials. It's being tested to see how well it helps patients with various cancers, including pancreatic, liver, and stomach cancer, find and enroll in trials. The study is also looking at the financial impact and potential benefits of using this AI tool. To join, you need to have solid or blood cancers and specific cancer-related biomarkers (like PD-L1, MSI, HER2/Neu, TMB, ABL1, BRAF, BRCA1, BRCA2, EGFR, KRAS, and many others). The study is currently enrolling patients, with a goal of 50,000 participants.

Study design
This is an observational study, meaning it watches what happens without giving specific treatments. It aims to enroll 50,000 patients.
What's involved
You would voluntarily enroll in the registry. There are no extra tests or procedures required by the study; all treatment decisions are made by your doctor.
Compensation
Not stated in the trial record.
Follow-up
Your eligibility for clinical trials will be measured for about one year. Data collection will occur every 3 months for about 12 months after the last patient enrolls.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03452774

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

Recruiting
Not specifiedAll AgesObservational
Massive Bio, Inc.
~50,000 participants
Updated 2025-10-28 on ClinicalTrials.gov
What's tested:Clinical Trial Matching

At a glance

Recruiting sites
68 of 68 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of patients Eligible for CTE versus Actual CTE
Measured over Through study completion, an average of 1 year
Cancer, Metastatic
Cancer
Cancer of Pancreas
Cancer of Liver
Cancer of Stomach
Cancer Liver
Cancer of Rectum
Cancer of Kidney
Cancer of Esophagus
Cancer of Cervix
Cancer of Colon
Cancer of Larynx
Cancer, Lung
Cancer, Breast
Cancer, Advanced
Cancer Prostate
Cancer of Neck
Cancer of Skin
Neuroendocrine Tumors
Carcinoma
Mismatch Repair Deficiency
BRCA Gene Rearrangement
Non Hodgkin Lymphoma
Leukemia
Non Small Cell Lung Cancer
Cholangiocarcinoma
Glioblastoma
Central Nervous System Tumor
Melanoma
Urothelial Carcinoma
Bladder Cancer
Ovarian Cancer
Endometrial Cancer
Testicular Cancer
Breast Cancer
COVID
Myelofibrosis
Myeloproliferative Neoplasm
Myeloproliferative Disorders
Follicular Lymphoma
Mantle Cell Lymphoma
Marginal Zone Lymphoma
Myelodysplastic Syndromes

NCT03452774

Where you'd take part

This study runs at 68 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Massive Bio SYNERGY-AI site

    Birmingham, Alabamastudy coordinator listed

    Recruiting

  • Massive Bio SYNERGY-AI site

    Mobile, Alabamastudy coordinator listed

    Recruiting

  • Massive Bio SYNERGY-AI site

    Scottsdale, Arizonastudy coordinator listed

    Recruiting

  • Massive Bio SYNERGY-AI site

    Little Rock, Arkansasstudy coordinator listed

    Recruiting

  • Massive Bio SYNERGY-AI site

    Duarte, Californiastudy coordinator listed

    Recruiting

  • Massive Bio SYNERGY-AI site

    Irvine, Californiastudy coordinator listed

    Recruiting

  • Massive Bio SYNERGY-AI site

    La Jolla, Californiastudy coordinator listed

    Recruiting

  • Massive Bio SYNERGY-AI site

    Orange, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Selin Kurnaz, PhD · PRINCIPAL_INVESTIGATOR · Massive Bio, Inc.

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Pts with solid and hematological malignancies;
Pts cancer-related biomarkers, gene variants, fusion and rearrangements (by immunohistochemistry, PCR, FISH or NGS): PD-L1, MSI (MMR), Claudin18.2, HER2/Neu, Tumor mutational burden/load (TMB), ABL1, ACVR1B, AKT1, AKT2, AKT3, ALK, APC, AR, ATM, ATRX, AURKA, AURKB, BAP1, BCL2, BCL6, BRAF, BRCA1, BRCA2, BTK, CCND1, CCND2, CCND3, CDK4, CDK6, CDKN1A/B, CEBPA, CHEK1, CHEK2, CSF1R, CTNNB1, DAXX, DDR1/2, DNMT3A, EGFR, ERBB2, ERBB3, ERBB4, ERCC4, ER, ESR1, FANCA, FAS, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GATA3, GATA6, GNAS, HDAC1, HGF, HRAS, IDH1, IDH2, IGF1R, JAK1, JAK2, JAK3, KDR (VEGFR2), KIT, KRAS, MAP2K2 (MEK2), MAP3K1, MCL1, MDM2, MDM4, MEN1, MET, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCL (MYCL1), NF1, NF2, NOTCH1, NPM1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PARP1, PARP2, PARP3, PBRM1, PDCD1 (PD1), PDCD1LG2 (PD-L2), PDGFRA, PDGFRB, PIK3C, PMS2, POLD1, POLE, PRDM1, PTCH1, PTEN, RAF1, RB1, RET, RICTOR, ROS1, RPTOR, SDHA/B/C, SMAD, SMARC, SMO, STK11, TGFBR2, TP53, TSC1, TSC2, VEGFA, VHL, WT1, ZNF217, ZNF703, CEACAM, NRG1, among others.
Decision to consider clinical trial pre-screening enrollment (CTE) by primary provider and/or patient

Exclusion

ECOG PS \> 2;
Abnormal organ function;
Hospice enrollment
  • Proportion of patients Eligible for CTE versus Actual CTEThrough study completion, an average of 1 year

    CTE Accrual