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Ischemic Conditioning During Air Transport for Acute Stroke

This study, called "Ischemic Conditioning During Air tRansport Save penUmbral Tissue," is looking at a treatment called remote limb ischemic conditioning (RLIC) for people who have had a suspected acute ischemic stroke. RLIC uses a special blood pressure device (Doctormate) to inflate cuffs on your limbs for short periods. The goal is to see if it's possible for medical crews to deliver this treatment safely during helicopter transport to a hospital that can perform a procedure called thrombectomy. You might be able to join if you are between 18 and 80 years old, have symptoms of a large vessel blockage in your brain, and are being transported by air for treatment. The study will measure how many cycles of RLIC are completed during your flight.

Study design
This is an interventional study with a planned enrollment of 10 participants. It is not specified if it is randomized or blinded.
What's involved
If you participate, you will receive RLIC treatment using the Doctormate device during your air transport. You will be evaluated for side effects upon arrival at the hospital.
Compensation
Not stated in the trial record.
Follow-up
Participants will be evaluated upon arrival at the comprehensive stroke center. The primary endpoint is measured at the duration of the flight, typically 30 minutes to 3 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03481205

Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Recruiting
NAAges 18–80InterventionalDevice feasibility
Enrique Leira
~10 participants
Updated 2025-11-10 on ClinicalTrials.gov
What's tested:Ischemic conditioning device

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evaluate the feasibility of delivering RLIC by air medical crews in patients with AIS. This will be assessed by recording the number of cycles completed during transport.
Measured over The duration of the flight, typically 30 min-3 hours depending on weather and distance of the community hospital

Conditions

Acute Stroke

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Acute Ischemic StrokeLarge Vessel Occlusion

NCT03481205

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Iowa

    Iowa City, Iowano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Enrique Leira, MD · PRINCIPAL_INVESTIGATOR · University of Iowa Hospitals and Clinics- 200 Hawkins Dr, Iowa City, IA 52242

Who to contact

Amir Shaban, MD
[email protected]
3193568755
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

What this trial measures

  • Evaluate the feasibility of delivering RLIC by air medical crews in patients with AIS. This will be assessed by recording the number of cycles completed during transport.The duration of the flight, typically 30 min-3 hours depending on weather and distance of the community hospital

    Feasibility will be assessed based on the number of cycles performed during transportation by air as follows: For flight time of duration of ≥ 60 minutes, ≥ 60% of subjects should receive 4 cycles of RLIC. For flight time of duration of 30-60 minutes, ≥ 60% of subjects should receive at least 3 cycles of RLIC. For flight duration of \< 30 minutes, ≥60% of subjects should receive at least 2 cycle of RLIC.