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Knee Osteoarthritis Treatment: PRP vs. Hyaluronic Acid

This study is comparing two treatments for knee osteoarthritis: Platelet-Rich Plasma (PRP) and Euflexxa (a hyaluronic acid, or HA, treatment). Researchers want to see if PRP is better than Euflexxa at improving cartilage thickness in the knee, which will be measured using MRI scans. They will also look at changes in pain and how well your knee functions. You might be able to join if you are 18-75 years old, have chronic knee pain for over 3 months, and have moderate osteoarthritis (Kellgren-Lawrence Grade 2 or 3). About 100 people will participate in this study, which is currently unclear if it's recruiting.

Study design
This is a randomized study where participants are assigned to either PRP or Euflexxa treatment. About 100 people will participate, and the radiologist who scores the MRI results will not know which treatment you received.
What's involved
You would undergo screening blood work. The study duration is approximately 13 months, with final data collected 12 months after treatment.
Compensation
Not stated in the trial record.
Follow-up
Your cartilage thickness will be measured at 6 and 12 months after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03491761

Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

Recruiting
PHASE2Ages 18–75InterventionalTreatment
Endeavor Health
~100 participants
Updated 2024-02-28 on ClinicalTrials.gov
What's tested:PRP TreatmentHA Treatment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cartilage Thickness on MRI
Measured over 6 and 12 months

Conditions

Knee Osteoarthritis

Explore related trials

Osteoarthritis of knee

NCT03491761

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • NorthShore University HealthSystems

    Skokie, Illinoisstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jason L Koh, MD, MBA · PRINCIPAL_INVESTIGATOR · Clinical Chairman, Dept. of Orthopaedics

Who to contact

Jason L Koh, MD, MBA
[email protected]
224-251-3481
Email the study team

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Eligibility criteria

Inclusion

Ability to provide informed consent
Chronic pain (\>3 months)
Grade 2 -3 according to Kellgren- Lawrence (K-L) classification system (using bilateral anteroposterior radiograph image acquired while the patient is weight-bearing with both knees in full extension)
Minimum score of 40 out of possible 100 on the VAS (Visual Analog Scale) for pain
Age 18 to 75 years old
Physical exam and medical history
Complete Blood Count to include platelets and differential (CBC with Diff) within normal limits
C-Reactive Protein (CRP) within normal limits
Sed Rate (ESR) within normal limits
Survey of current medications

Exclusion

Presence of major axial deformity (\>5° valgus or varus deviation)
Surgery on target knee within 12 months prior to scheduled treatment
Autoimmune disorder
Active infections
Immuno-suppression (e.g., AIDS, etc.)
Anti-coagulant therapy
Use of NSAIDs 5 days prior to blood draw or up to 7 days after last PRP / HA treatment
Hemoglobin (Hg) \<12 g/dL
Platelet counts (PLT) \<150,000 /mm3
Previous infiltrative treatment within 3 weeks prior to scheduled treatment
Pregnancy/Breastfeeding
Hypersensitivity to HA
Inability to complete an MRI due to metal implants or claustrophobia
Diabetes
Active treatment for a malignancy
Active wound in the knee
Recent history of knee trauma
Vasovagal history
An injection of hyaluronic acid (HA) or platelet-rich plasma (PRP) to the affected knee within the last two years.
In the judgment of the investigator, the patient is unable to perform and/or complete all of the study visits or treatments required.

What this trial measures

  • Cartilage Thickness on MRI6 and 12 months

    Evaluation of changes from baseline in central medial femorotibial compartment cartilage thickness measurements (via ordered value method) using quantitative T1 and cartilage compositional changes using T2 MRI at 6 and 12 months.