Observational Study on OCT for Irregular Corneas
This study aims to improve how doctors detect, classify, monitor, and treat irregular corneas, which are problems with the clear front part of your eye. This includes conditions like keratoconus (a thinning of the cornea), corneal warpage from contact lenses, and dry eye. Researchers will use a device called Optical Coherence Tomography (OCT) to better understand these conditions. The main goals are to develop a system using OCT to classify corneal irregularities, find better ways to track the progression of keratoconus, and improve a laser treatment called phototherapeutic keratectomy (PTK) for irregular corneas. You might be able to join if you are between 14 and 85 years old and have certain eye conditions like keratoconus or contact lens-related corneal warpage.
- Study design
- This is an observational study planning to include 445 participants. It uses the Optical Coherence Tomography (OCT) device to classify corneal irregularities.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study aims to develop tools for detecting keratoconus progression over 4 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
OCT in Diagnosis of Irregular Corneas
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Yan Li, PhD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Develop OCT-based system to classify and evaluate corneal-shape irregularities1 day
Clinical classification of keratoconus, epithelial deformation, stromal addition/subtraction, stromal distortion, and healthy controls by OCT. Primary measurements will be corneal and epithelial thicknesses assessed in micron units.
- Develop OCT-based system to classify and evaluate corneal-shape irregularities1 day
Secondary measurement will be OCT corneal shape assessed in Diopter units.
- Develop OCT metrics for more sensitive detection of keratoconus progression4 year
Primary measurements will be OCT corneal and epithelial thicknesses assessed in micron units.
- Develop OCT metrics for more sensitive detection of keratoconus progression4 year
Secondary measurement will be OCT corneal shape assessed in Diopter units.
- Develop OCT- and topography-guided phototherapeutic keratectomy (PTK) for irregular corneas1 year
The primary goal is to improve the post-procedural outcome of uncorrected and best corrected visual acuity. This will be measured in feet by conventional Snellen fraction of 20/xx.
- Develop OCT- and topography-guided phototherapeutic keratectomy (PTK) for irregular corneas1 year
The secondary goal is to improve the post-procedural outcome of refractive error. This will be measured in Diopter units.