Panitumumab-IRDye800 for Malignant Glioma Surgery
This study is testing a new way to help surgeons see brain tumors better during surgery. It uses a special substance called panitumumab-IRDye800, which is given through an IV. This substance attaches to tumor cells and glows when a special camera (POINPOINT-IR9000) is used. This might help surgeons tell the difference between tumor cells and healthy brain tissue, and find small tumors that are hard to see otherwise. The main goal is to see if panitumumab-IRDye800 is safe and what dose works best. You could join if you are 18 or older, have a suspected or confirmed diagnosis of glioblastoma or vestibular schwannoma, and are planning to have surgery to remove your tumor. The study is currently unclear on its recruitment status and plans to enroll 46 participants.
- Study design
- This is a Phase 1/2 study that will test different doses of panitumumab-IRDye800. It will involve a total of 46 participants.
- What's involved
- You would receive panitumumab-IRDye800 through an IV and undergo near-infrared imaging during your tumor removal surgery.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your safety will be monitored for up to 30 days after receiving the study treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Lindsay Moore, MD · PRINCIPAL_INVESTIGATOR · Stanford University
Who to contact
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What this trial measures
- Number of grade 2 or higher adverse events which have been determined to be clinically significant and definitely, probably, or possibly related to the study treatment, graded according to Common Terminology Criteria for Adverse Effects (CTCAE) v. 4.0Up to 30 days
Descriptive statistical analysis of subject disposition, baseline characteristics, exposure to study drug, and adverse events will be performed. Descriptive statistics for continuous data will include mean, standard deviation, median, minimum, maximum, and inter-quartile values. Frequencies and percentages will be used to summarize categorical data.