Personalized Treatment in Thyroid Disorders with CoTI

This study is testing a device called the Cervical Collar Therapy Indicator (CoTI) for people with thyroid cancer or Graves' disease. The CoTI is a collar worn around the neck that continuously measures radiation exposure during radioiodine treatment. Researchers believe this device will provide more accurate estimates of radiation exposure to thyroid tissue compared to current methods. The goal is to help doctors give the best possible dose of radioiodine to each patient, potentially reducing side effects and improving treatment success. The study will evaluate how much the radioiodine levels vary in patients over 6-9 months. You may be able to join if you are between 21 and 65 years old, understand English, and have either Graves' disease or certain types of thyroid cancer requiring radioiodine treatment. The current status of the study is unclear.

Study design
This is an interventional study with a planned enrollment of 10 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will evaluate radioiodine kinetics for patients over 6-9 months.

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NCT03517579

Personalized Treatment in Thyroid Disorders

Recruiting
NAAges 21–65InterventionalDiagnostic
Johns Hopkins University
~10 participants
Updated 2025-10-15 on ClinicalTrials.gov
What's tested:Cervical Collar Therapy Indicator (COTI)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evaluation of the Variability in radioiodine kinetics for patients with thyroid cancer and graves disease
Measured over 6-9 months
Thyroid Cancer
Graves Disease
1 sites across 1 states
Maryland1
  • Prasanna Santhanam, MBBS, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

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Eligibility criteria

Inclusion

Group I
Patients with Graves' disease confirmed by laboratory testing.
Patients able to understand English and able to follow instructions. Group II
Patients with intermediate and high risk differentiated thyroid cancer requiring radioiodine remnant ablation or moderately high dose I-131 for treatment of residual cervical disease.
Persons able to understand simple English and able to follow instructions.

Exclusion

Patients with diseases involving cervical spine, such as spondylosis and severe degenerative joint disease.
Pregnant Women, elderly and persons unable to understand simple instructions
  • Evaluation of the Variability in radioiodine kinetics for patients with thyroid cancer and graves disease6-9 months

    Radioactive iodine uptake at different time points will be taken over a 24 hour period (7 days for thyroid cancer) and then the Area Under the Curve (AUC) will be Plotted.The AUC would then be correlated with the 24 hour uptake in Graves and day 7 uptake for thyroid cancer.We will use non-parametric tests to measure the correlation