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Aerobic Exercise for Obesity and Vascular Health

This study is looking at how aerobic exercise training affects people with obesity. Researchers want to understand if exercise can help reduce inflammation and improve blood vessel function by changing how genes are expressed (DNA methylation). You might be able to join if you are 18-50 years old, have a BMI of 35 or higher, and are approved for bariatric surgery. The study aims to see if aerobic exercise can change DNA methylation related to inflammation in obese individuals. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 80 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will undergo twelve weeks of aerobic exercise training. The primary endpoint, DNA methylation status, will be measured at Month 24-30.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for DNA methylation status for up to 24-30 months after the intervention.

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NCT03527420

DNA Methylation and Vascular Function

Recruiting
NAAges 18–50InterventionalPrevention
University of Illinois at Chicago
~80 participants
Updated 2025-09-15 on ClinicalTrials.gov
What's tested:Exercise training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
DNA methylation status of adipocytokines in obese individuals
Measured over Month 24-30

Conditions

Obesity
Vascular Dysfunction

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Abeer Mohamed, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Illinois at Chicago

Who to contact

Abeer Mohamed, MD, PhD
[email protected]
3127539998
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

BMI ≥ 35 kg/m2
Between ages 18-50 years
Not pregnant
Approved for a bariatric surgery

Exclusion

To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
Pregnant women will be excluded, as they will not be eligible for bariatric surgery
Current smokers
Currently abusing alcohol or drugs

What this trial measures

  • DNA methylation status of adipocytokines in obese individualsMonth 24-30

    DNA methylation of 20 preselected adipocytokines using "Amplicon sequencing-based methylation profiling" will be measured in fat tissue collected from obese individuals who are scheduled for bariatric surgery before and after 12 weeks of aerobic exercise training.