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Observational Study on Anesthesia and Cognitive Function in Retinoblastoma Patients

This observational study is looking at whether having multiple anesthesia exposures affects how the brain develops (neurodevelopment) in children who have been treated for retinoblastoma, a type of eye cancer. Researchers will compare the brain development of children who received multiple anesthetics with those who have never had anesthesia. They will use several tests, including the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) to measure overall intelligence, the California Verbal Learning Test to assess memory, and the Beery Developmental Test of Visual Motor Integration for visual-motor skills. The study is open to children aged 6 to 17 years old. The main goal is to see if there's a difference in neuropsychological test scores after about 6 weeks.

Study design
This is an observational study with a planned enrollment of 75 participants. It is not a randomized trial and does not involve new treatments.
What's involved
Participants will undergo neuropsychological testing, including assessments like the WISC-V, California Verbal Learning Test, Beery Developmental Test, Grooved Pegboard Test, and a Behavior Assessment System for Children/Parent Report.
Compensation
Not stated in the trial record.
Follow-up
Neuropsychological testing results will be measured at 6 weeks.

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NCT03546387

Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients

Recruiting
Not specifiedAges 6–17Observational
Memorial Sloan Kettering Cancer Center
~75 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)California Verbal Learning Test, Children's VersionBeery Developmental Test of Visual Motor Integration, 6th editionGrooved Pegboard TestBehavior Assessment System for Children/Parent Report

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Comparing scores in neuropsychological testing results
Measured over 6 weeks

Conditions

Pediatric Retinoblastoma
Retinoblastoma

Explore related trials

Retinoblastoma

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Vittoria Arslan Carlon, MD · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

Who to contact

Vittoria Arslan Carlon, MD
[email protected]
212-639-2680
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥ 6 and \< 17 years old

Exclusion

Diagnosis of any secondary disease associated with developmental delay
History of second cancer diagnosis
Legal Blindness
Past surgery of any type, with the exception of enucleation for retinoblastoma
Past exposure to anesthesia for surgical intervention
More than one anesthesia encounter for surgical intervention before diagnosis at MSK
Past External Beam Radiation for treatment of retinoblastoma
Past systemic chemotherapy
Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish

What this trial measures

  • Comparing scores in neuropsychological testing results6 weeks

    The primary outcome is based on the Wechsler Intelligence Scale for Children, 5th edition (WISC-V) measured at follow up. The 5 primary index scores on the WISC-V (Verbal Comprehension, Visual Spatial, Fluid Reasoning, Working Memory, and Processing Speed) are based on 10 subtests and represent intellectual functioning in different cognitive areas. Similar to the FSIQ, the primary index scores are on a standard score metric with a mean of 100 (SD=15). The WISC-V consists of 16 subtests; each subtest is based on a scaled score metric with a mean of 10 and standard deviation (SD) of 3. Performance on these domain-specific subtests will be summarized and analyzed similarly to the FSIQ.