This study is looking at whether adding Daromun, given as injections into tumors, before surgery can help people with advanced melanoma (skin cancer) that has spread locally. You might be eligible if you have Stage IIIB, IIIC, or IIID melanoma that can be surgically removed. The study compares Daromun plus surgery and standard follow-up treatment to just surgery and standard follow-up treatment. Researchers want to see if Daromun helps prevent the cancer from coming back (recurrence-free survival). The study is currently unclear on its recruitment status and plans to enroll 186 participants.

Study design

This is an open-label, randomized study with two groups, involving 186 participants. You would be randomly assigned to one of two treatment groups.

What's involved

You would receive Daromun injections once a week for up to 4 weeks, followed by surgery and then standard follow-up therapy. You will be followed for up to 6 years after randomization.

Compensation

Not stated in the trial record.

Follow-up

Your health will be monitored for up to 6 years after you join the study to track if the cancer returns and your overall survival.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.