Observational Study of Gut and Skin Microbiome in Vitiligo

This study is looking at the gut and skin microbiome (the community of tiny living things like bacteria that live on and inside us) in people with vitiligo. Researchers want to see if these microbiomes are different in people with vitiligo compared to healthy individuals. They will compare people with vitiligo who have active disease (spreading) and stable disease (not spreading) to healthy volunteers. The study aims to understand if there are differences in the types and amounts of these tiny organisms. To join, you need to be between 18 and 89 years old. The study is considered successful if it can show differences in the microbiome composition and how vitiligo progresses over 12 months. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will observe participants without giving any specific treatments. It plans to enroll 100 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be observed for 12 months to measure microbiome composition and disease progression.

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NCT03577327

The Gut and Skin Microbiome in Vitiligo Disease Progression

Recruiting
Not specifiedAges 18–89Observational
Northwestern University
~100 participants
Updated 2026-06-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Microbiome composition
Measured over 12 months
+1 more outcome measured
Vitiligo
Healthy
1 sites across 1 states
Illinois1
  • I. Caroline Le Poole · PRINCIPAL_INVESTIGATOR · Northwestern University

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Eligibility criteria

Inclusion

Patients with and/or without vitiligo lesional expansion over the past year.
Age/sex-matched controls who do not have a diagnosis of vitiligo
Subjects who are age 18-89 years of age at time of enrollment
Subjects who are able and willing to give informed consent for this study and the Dermatology Tissue Acquisition and Biorepository (STU00009443)

Exclusion

Subjects who are younger than 18 years of age or 90 years of age or older
Subjects who are unable to give consent
  • Microbiome composition12 months

    Diversity analysis of microbiome samples in control subjects versus vitiligo subjects (measured by number of bacteria species/sample)

  • Disease Progression12 months

    Disease progression in control subjects versus vitiligo subjects (measured by VASI score (0-100)).