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Tamsulosin for Preventing Urinary Retention After Thoracic Surgery

This study is looking at whether a medication called Tamsulosin (Flomax) can help prevent a common problem called post-operative urinary retention (POUR) after chest surgery. POUR is when you can't urinate after surgery, which can be uncomfortable and lead to needing a catheter. Flomax is approved to help improve urinary flow in men with enlarged prostates. Researchers believe that giving Flomax before and after surgery might reduce POUR. They are testing two different schedules for taking Flomax: either for one week before surgery or for three days before surgery. The study aims to see if men who take Flomax have a lower incidence of POUR. This study is for men aged 50 and older who are having certain types of minimally invasive chest surgery and are not currently taking Flomax or similar medications.

Study design
This interventional study plans to enroll 127 male participants aged 50 and older. It is testing two different schedules for taking Tamsulosin (Flomax) to prevent urinary retention after thoracic surgery.
What's involved
Participants will take Tamsulosin (Flomax) daily for either one week or three days before surgery, and continue taking it after surgery until they can urinate normally.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, urine volume, will be measured 8 hours after thoracic surgery.

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NCT03609580

Post-operative Urinary Retention (POUR) Following Thoracic Surgery

Recruiting
PHASE1Ages 50+InterventionalTreatment
Hackensack Meridian Health
~127 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:Tamsulosin - 1 weekTamsulosin - 3 days

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Volume of urine (cc) post thoracic surgery in patients that received Flomax, 0.4mg/day for a week before surgery
Measured over 8 hours

Conditions

Urinary Retention

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Where it's being run

1 sites across 1 states
New Jersey1

Study leadership

  • Michael Spallone, MD · PRINCIPAL_INVESTIGATOR · Hackensack Meridian Health

Who to contact

Michael Spallone, MD
[email protected]
551-996-2000 · ext. 5960
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Using Flomax already
Allergy to Flomax or sulfa drugs
Current use of alpha blockers or alpha agonists
Resting systolic blood pressure \<100
Orthostatic hypotension of \>20mm Hg (millimeters of mercury) Systolic and/or 10mm Hg diastolic pressure from sitting to standing (after 2 minutes of standing) as measured at the time of consent
Known diagnosis of congestive heart failure and valvular heart disease
History of prostate surgery (prostatectomy, trans-urethral resection)

What this trial measures

  • Volume of urine (cc) post thoracic surgery in patients that received Flomax, 0.4mg/day for a week before surgery8 hours

    The absence of voiding naturally after undergoing thoracic surgery needing an intervention as a Foley catheter or a catheterization. Documentation for first void, Post bladder scan showing more that 300cc of residual urine in the bladder (failure to urinate), or following spontaneous urination if there is more than 300cc of residual urine in the bladder (inadequate urination)