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Enhancing Recovery After Upper Extremity Nerve Repair

This study is exploring a new way to improve recovery for people who have had hand transplants, hand re-attachments, or other upper extremity nerve repairs. It combines a brain stimulation method called transcranial direct current stimulation (tDCS) with Modified Constraint Induced Movement Therapy (CIMT). tDCS uses a small electric current to change brain activity, and CIMT involves restricting the use of your unaffected arm while you practice tasks with the affected arm. The goal is to see if this combination can help your brain adapt and improve movement and sensation. You might be able to join if you are an adult who has had a unilateral (one-sided) hand transplant or successful hand re-attachment, and are in the chronic recovery stage (about 12-18 months after surgery). The main way success will be measured is by looking at changes in your hand function using a specific test called the Dellon Modified Moberg Pick-Up Test, measured at two weeks after the intervention.

Study design
This is an interventional study planning to enroll 180 participants. It is testing two interventions: transcranial direct current stimulation (tDCS) and Modified Constraint Induced Movement Therapy (CIMT).
What's involved
You would participate in behavioral training combined with transcranial direct current stimulation. Your hand function will be measured at the beginning of the study and immediately after the intervention, within three days.
Compensation
Not stated in the trial record.
Follow-up
Your hand function will be measured at Baseline and immediately after the end of the intervention (within +/- 3 days).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03610763

Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair

Recruiting
NAAges 18+InterventionalTreatment
University of Missouri-Columbia
~180 participants
Updated 2024-06-12 on ClinicalTrials.gov
What's tested:Transcranial Direct Current StimulationModified Constraint Induced Movement Therapy

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline Dellon Modified Moberg Pick-Up Test performance at two weeks.
Measured over Baseline, immediately after end of intervention (+/- 3 days).

Conditions

Hand Transplantation
Peripheral Nerve Injuries
Neurologic Rehabilitation

Explore related trials

AmputationHand TransplantationPeripheral Nerve Injury

NCT03610763

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Christine Kleinert Institute for Hand & Microsurgery

    Louisville, Kentuckystudy coordinator listed

    Recruiting

  • University of Missouri

    Columbia, Missouristudy coordinator listed

    Recruiting

  • Washington University School of Medicine

    St Louis, Missouristudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Scott H Frey, Ph.D., Ed.M. · PRINCIPAL_INVESTIGATOR · University of Missouri-Columbia

Who to contact

Scott H Frey, Ph.D., Ed.M.
[email protected]
573-882-4572
Email the study team

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Eligibility criteria

Inclusion

Individuals whom have received a unilateral allogeneic transplantation proximal to the wrist and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).
Individuals whom have undergone a complete amputation the hand between the wrist and elbow followed by successful re-attachment and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).
Individuals whom have undergone repairs of the median, ulnar, or other related or nearby nerve(s) following complex volar forearm lacerations or other injuries between the distal wrist crease and the flexor musculotendinous junctions. Individuals must be at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).

Exclusion

Individuals with significant/severe brain trauma
Serious psychiatric conditions
Chronic or severe neurological conditions.
Current pregnancy
History of seizures or unexplained loss of consciousness
Metallic implants above the chest
Certain implanted medical devices.

What this trial measures

  • Change from Baseline Dellon Modified Moberg Pick-Up Test performance at two weeks.Baseline, immediately after end of intervention (+/- 3 days).

    This functional test measures quality of sensibility of the hand. This outcome measure will investigate any change in participant performance between pre- and post-intervention sessions of the Dellon Modified Moberg Pick-Up Test.