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Fasting Mimicking Diet for Ulcerative Colitis

This study is looking at how a special diet, called a Fasting Mimicking Diet, affects people with mild to moderate Ulcerative Colitis (UC), a type of Inflammatory Bowel Disease. The diet is designed to give you the benefits of fasting while still allowing you to eat certain foods. Researchers want to see if this diet can reduce inflammation and improve your quality of life. You may be able to join if you are between 18 and 70 years old and have mild to moderate UC. The study will measure your disease score using a tool called the partial Mayo score to see if the diet helps. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 75 participants to compare a Fasting Mimicking Diet with a Regular Diet.
What's involved
Participants will follow a 5-day reduced calorie Fasting Mimicking Diet once a month for three cycles, with a regular diet for the rest of each month.
Compensation
Not stated in the trial record.
Follow-up
Your disease score will be compared up to 14 days before starting the diet and within 6 days after completing the third cycle.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03615690

The Influence of a Fasting Mimicking Diet on Ulcerative Colitis

Recruiting
NAAges 18–70InterventionalTreatment
Stanford University
~75 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:Fasting Mimicking DietRegular Diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinical response as per partial Mayo score
Measured over Comparison of disease score up to 14 days before starting Cycle 1, and within 6 days after completing Cycle 3. 1 cycle of IRCD lasts 5 days and is administered once a month, followed by regular diet for the rest of the month.

Conditions

Inflammatory Bowel Disease
Diet Modification
Ulcerative Colitis

Explore related trials

Ulcerative Colitis

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Sidhartha R Sinha, MD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

Touran Fardeen
[email protected]
6507367311
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Mild to moderate Ulcerative Colitis on the partial Mayo Score out of 9 (score between 2 to 7)
Age of 18-70 at start of study (inclusive)

Exclusion

Women who are pregnant or nursing or expect to be pregnant
Individuals allergic to nuts
Individuals with a body mass index (BMI) lower than 18
Individuals diagnosed with a serious medical condition as defined by the patient's physician, unless approved in writing by a physician
Individuals who have been severely weakened by a disease or medical procedure,
Individuals who are taking medication which may not be safely consumed with a calorie restricted diet
Individuals with diabetes who are taking anti-diabetic drugs associated with risk of hypoglycemia
Individuals with more than mild-moderate cardiovascular disease or life-threatening cancer (as determined by patient's physician) unless approved by a physician
Individuals with history of severe cardiac disease (particularly uncompensated congestive heart failure NYHA grade 2 or more or LVEF \< 40%)
Individuals with a history of syncope
Individuals with dietary needs incompatible with the FMD meal plan
Individuals with liver or kidney disorders that may be affected by very low glucose and protein content of the diet.
Patients on a caloric restricted diet will also be excluded.
Patients with relevant prior gastrointestinal surgery and consequences such as short bowel syndrome, ostomy of small or large intestine, hemi- or total colectomy, proctocolectomy, ileoanal pouch will be excluded.

What this trial measures

  • Clinical response as per partial Mayo scoreComparison of disease score up to 14 days before starting Cycle 1, and within 6 days after completing Cycle 3. 1 cycle of IRCD lasts 5 days and is administered once a month, followed by regular diet for the rest of the month.

    Defined as a decrease from baseline in the partial Mayo score of \>= 2 points and either a rectal bleeding subscore of \<=1 or a decrease in the rectal bleeding subscore of \>=1 point, or achieving a partial Mayo score \<2. The partial Mayo score consists of the subscores for stool frequency, rectal bleeding, and PGA, omitting endoscopy.