Vitamin D Homeostasis in Sarcoidosis

This study is looking at how vitamin D levels affect sarcoidosis (a disease causing inflammation in organs) and if giving vitamin D can help. If you have sarcoidosis and low vitamin D, you might receive either Ergocalciferol (Vitamin D2) or a placebo (a sugar pill that looks like the real medicine). Some people with sarcoidosis who have normal vitamin D levels will also be included for comparison. Researchers will measure changes in your lung function over 24 weeks to see if the vitamin D treatment makes a difference. To join, you should be at least 21 years old, have a stable medical condition, and have normal calcium levels.

Study design
This is an interventional study involving 90 participants. Half of the vitamin D insufficient sarcoidosis patients will receive Ergocalciferol, while the other half will receive a placebo.
What's involved
Your lung function will be measured at the beginning of the study and again after 24 weeks.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 24 weeks after starting the intervention to measure changes in lung function.

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NCT03621553

Vitamin D Homeostasis in Sarcoidosis

Recruiting
PHASE4Ages 21+InterventionalTreatment
University of Texas Southwestern Medical Center
~90 participants
Updated 2026-01-02 on ClinicalTrials.gov
What's tested:ErgocalciferolPlaceboCalcium Citrate with Vitamin D2

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in lung function from baseline
Measured over Baseline and 24 weeks
Sarcoidosis
Vitamin D Insufficiency
1 sites across 1 states
Texas1
  • Connie Hsia, MD · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center

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Eligibility criteria

Inclusion

Stable medical condition defined as no hospitalization or emergency room visit in the previous 3 months
No evidence of active pulmonary or systemic infection
No other active inflammatory disease,
No active malignancy.
Normal serum ionized calcium level

Exclusion

Hospitalization or emergency room visit in the previous 3 months
Evidence of active pulmonary or systemic infection
Evidence of active other inflammatory disease
Evidence of active malignancy
Elevated serum ionized calcium level
  • Change in lung function from baselineBaseline and 24 weeks

    (Measurement at end of study)/(measurement at enrollment)