Observational MRI Study in Bronchopulmonary Dysplasia (BPD)

This study is looking at how the lungs develop in babies, especially those with Bronchopulmonary Dysplasia (BPD), a breathing problem common in premature infants. Researchers will use an MRI device (a machine that uses magnets and radio waves to create detailed pictures of organs and structures inside the body) to take images of the lungs. They will also use Polysomnography (a sleep study that records brain waves, oxygen levels, heart rate, and breathing during sleep) to understand breathing issues. The main goal is to see how lung anatomy looks on MRI. This study is for NICU patients up to 4 months old, but excludes those with certain other health conditions. The study is currently unclear on its recruitment status and plans to enroll 160 participants.

Study design
This is an observational study involving 160 participants. It is not a randomized trial and does not specify a phase.
What's involved
Participants will have up to three MRI visits, with the first after initial evaluation, the second about one month later, and the third before discharge. Some participants may also have a brief inpatient polysomnogram in the NICU.
Compensation
Not stated in the trial record.
Follow-up
Anatomic phenotypes using MRI are measured at baseline, but no further follow-up duration is specified.

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NCT03657693

MRI in BPD Subjects

Recruiting
Not specifiedUp to 4Observational
Children's Hospital Medical Center, Cincinnati
~160 participants
Updated 2026-01-07 on ClinicalTrials.gov
What's tested:NICU MRIPolysomnography

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Anatomic phenotypes using MRI
Measured over baseline
Bronchopulmonary Dysplasia

NCT03657693

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Megan Schmitt

    Cincinnati, Ohiostudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Jason Woods, PhD · PRINCIPAL_INVESTIGATOR · Children's Hospital Medical Center, Cincinnati

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Eligibility criteria

Inclusion

any term age NICU patient

Exclusion

\- ECMO,
Evidence of congenital diseases that may affect lung development, such as congenital diaphragmatic hernia,
Suspected muscular dystrophy or neurologic disorder that may affect lung development.
Significant genetic or chromosomal abnormalities that may affect lung development
Evidence of any respiratory infection at the time of imaging (imaging may be rescheduled for a common viral infection such as a cold).
  • Anatomic phenotypes using MRIbaseline

    Investigate parenchymal and vascular structures, regional cardiopulmonary function, and dynamic airway collapse in BPD infants during quiet unsedated breathing.