Caffeine Consumption in Glaucoma Patients and Healthy Subjects

This study is looking at how caffeine affects blood flow in the back of the eye for people with glaucoma and healthy individuals. Participants will receive one 200 mg caffeine tablet. Researchers will measure blood flow changes in the back of your eye before and after taking caffeine using a special imaging tool called optical coherence tomography angiography (OCTA). This helps them see how caffeine might decrease blood flow. The study aims to enroll 80 people between 18 and 90 years old, including those with primary open-angle glaucoma and healthy individuals without eye disease. The current status of the study is unclear.

Study design
This is an interventional study, meaning participants will receive a specific intervention (a caffeine tablet). It plans to enroll 80 participants.
What's involved
You would complete baseline study tasks, then ingest a 200 mg caffeine tablet. Blood flow in the back of your eye will be measured at baseline, Hour 1, and Hour 2.
Compensation
Not stated in the trial record.
Follow-up
Blood flow changes are measured at Baseline, Hour 1, and Hour 2 after caffeine intake.

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NCT03675412

Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Recruiting
NAAges 18–90InterventionalDiagnostic
Wills Eye
~80 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:Caffeine tablet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Blood flow change in back of eye before and after caffeine
Measured over Baseline, Hour 1, Hour 2
Glaucoma, Primary Open Angle
1 sites across 1 states
Pennsylvania1
  • M. Reza Razeghinejad, MD · PRINCIPAL_INVESTIGATOR · Wills Eye Hospital

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Eligibility criteria

Inclusion

age 18 to 90 years
diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)
healthy subjects with no eye disease

Exclusion

Diseases, ophthalmic or systemic, that are likely to affect OCTA results
greater than moderate cataract
nystagmus
inability to look at target
macular degeneration other than mild drusen or pigmentary changes
diabetic retinopathy
neovascular glaucoma or non-glaucoma optic neuropathies
current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy
keratoconus, corneal ectasia, central corneal scarring
rheumatologic diseases or Raynaud's phenomena
pregnant and lactating women
mental illness or alcohol addiction
pre-existing bladder symptoms, cardiac disease or sleep disorder
refractive spherical diopter greater than 5 or cylinder greater than 3
possible tolerance to caffeine (drinking more than 1 cup coffee per day).
  • Blood flow change in back of eye before and after caffeineBaseline, Hour 1, Hour 2

    Optical Coherence Tomography Angiography (OCTA) will be obtained using the Avanti AngioVue High Definition (HD) OCTA by Optovue. Images will include standard 4.5mm HD disc scan, 6mm HD retina scan, regular optic nerve head (ONH) structural scan, 3D-disc baseline scan and a regular ganglion cell complex analysis (GCCA) structural scan. This will measure blood flow changes in the back of the eye by imaging vessel density in percentage before then 1 and 2 hours after caffeine.