Frailty Assessments for Older Patients with Blood Cancers

This observational study is looking at how frailty assessments can help predict outcomes for people aged 60 and older with acute leukemia or myelodysplastic syndromes (MDS). Researchers want to see if these assessments can tell how well patients will do after treatments like chemotherapy (e.g., "7+3," Vyxeos, clofarabine), CAR T-cell therapy (a type of immunotherapy), or allogeneic stem cell transplant (BMT). The study aims to understand if being frail, pre-frail, or not frail affects the risk of non-relapse mortality (death not caused by the cancer returning) one month after treatment. The study plans to enroll 20 participants, but its current status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without assigning specific treatments. It plans to include 20 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, non-relapse mortality, is measured at 1-month.

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NCT03680677

Frailty Phenotype Assessments to Optimize Treatment Strategies for Older Patients With Hematologic Malignancies

Recruiting
Not specifiedAges 60+Observational
Abramson Cancer Center at Penn Medicine
~20 participants
Updated 2026-08-12 on ClinicalTrials.gov
What's tested:Bone Marrow or Peripheral Blood Graft (BMT)Cancer-directed Therapy or Best Supportive CareFrailty Assessment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Non-Relapse Mortality (NRM) in Frail, Pre-Frail, and Non-Frail patients
Measured over 1-month
Leukemia, Acute
MDS
1 sites across 1 states
Pennsylvania1
  • Shannon McCurdy, MD · PRINCIPAL_INVESTIGATOR · Abramson Cancer Center

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  • Non-Relapse Mortality (NRM) in Frail, Pre-Frail, and Non-Frail patients1-month

    NRM will be defined as death without evidence of disease progression or relapse.