A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

{ "Long-Term Study of Ralinepag for Pulmonary Arterial Hypertension (PAH)", "This study is looking at the long-term effects of ralinepag in people who have pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs. It's an extension study for those who have already participated in an earlier study of ralinepag. The main goal is to see how safe ralinepag is over time by tracking any side effects you might experience for up to six years. To join, you must be at least 18 years old and have already been part of a previous ralinepag study for PAH. You'll continue to take ralinepag along with your current PAH medications. The study aims to enroll about 1000 participants. The current status of this study is unclear.", "design": "This is an open-label extension study, meaning you and your doctors will know you are receiving ralinepag. It is for participants who have already been in a Phase 2 or Phase 3 ralinepag study.", "commitments": "You will need to attend scheduled visits, follow the treatment plan, and complete laboratory tests and other study procedures for up to six years.", "compensation": "Not stated in the trial record.", "follow_up": "Your safety and side effects will be monitored for up to six years after starting the study.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03683186

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Enrolling by Invitation
PHASE3Ages 18+InterventionalTreatment
United Therapeutics
~1,000 participants
Updated 2026-02-20 on ClinicalTrials.gov
What's tested:Ralinepag

At a glance

Recruiting sites
0 of 190 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of subjects with treatment-emergent adverse events [Safety and Tolerability]
Measured over Up to 6 years
PAH
Pulmonary Hypertension
Pulmonary Arterial Hypertension
Hypertension
Connective Tissue Diseases
Familial Primary Pulmonary Hypertension
Vascular Diseases
Cardiovascular Diseases
Hypertension, Pulmonary
Lung Diseases
Respiratory Tract Disease

NCT03683186

Where you'd take part

This study runs at 190 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • "Onasseio" Cardiosurgery Hospital, Hemodynamic Research and Interventional Cardiology Dept., 356, Syggrou Avenue

    Athens, Greeceno site contact published

  • AHEPA General Hospital of Thessaloniki, A' Cardiology Clinic, 1 St. Kyriakidi Street

    Thessaloniki, Greeceno site contact published

  • AKH Wien, Innere Med. II, Kardiologie, Währingergürtel 18-20

    Vienna, Austriano site contact published

  • Allegheny General Hospital

    Pittsburgh, Pennsylvaniano site contact published

  • Århus Universitetshospital

    Aarhus, Denmarkno site contact published

  • Ascension Alexian Brothers

    Elk Grove Village, Illinoisno site contact published

  • Ascension Texas Cardiovascular

    Austin, Texasno site contact published

  • Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Viale del Policlinico, 155

    Roma, Italyno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Number of subjects with treatment-emergent adverse events [Safety and Tolerability]Up to 6 years

    The safety and tolerability of ralinepag will be evaluated by the Number of subjects with treatment-emergent adverse events